This is something that has been intriguing me for a while, so I would like to know if anyone experiences the same. My response to supplements (immune stimulating ones in particular) is generally the following. 1. Start to take new supplement (for example LDN, coconut oil or beta glucan). Within two days increased energy, better productivity, less anxiety, everything going nice. 2. Within a week to two, worsening of old symptoms, especially anxiety, brain fog, depression. Very slowly this improves but still is worse than baseline. 3. Quit supplement. Within around two days I feel great again, best ever. Brain fog much less, better focus, clarity and sleep. 4. Back to baseline. Within 3 or 4 days, the old baseline symptoms start to creep back. I respond like this to most CFS supplements, but sadly I've yet to find one which I could sustain the improvements on. I guess I should be happy that I get any type of response at all, as many people don't, but I'm still searching for a way to optimize the number of good days.