I've just started a probiotic regime, incl. Miyarisan. I wasn't noticing much at 2 tabs a day, so upped to 3 last night and woke up today feeling flu-ish and malaised, which I've experienced before. However, I also have a deep aching in both my of legs; it feels like I've just run a marathon or been to the gym .. I've never had this symptom before, and pain isn't a feature of my illness (despite being bedridden). I'm taking most of these symptoms as a good sign, but was just curious about the muscle aching.. has anyone had this before as part of increased immune activity or 'die off' or whatever? All of the trigger points in my thighs also feel very tender.