Discussion in 'Latest ME/CFS Research' started by Dolphin, Sep 19, 2017.
via Dr. Marc-Alexander Fluks
This could contain data from the MRC-funded study by Carmine Pariante.
Interferon alpha-induced persistent fatigue may be a better model of ME/CFS than the forced swim murine model of ME/CFS, which I have seen several studies use. In the forced swim model, they force mice to swim for a long time until they are totally exhausted, and then equate that exhaustion to ME/CFS. But I should think normal physical exhaustion in healthy animals or humans has little to do with the pathophysiology of ME/CFS.
So this interferon model may be an improvement on the forced swim model.
Thanks. I had a very quick skim (it's 445 pages) and thought that there could be some interesting info in there, but there was a lot of annoying credulous citing of poor quality psychosocial research, and I kept getting the impression that the author wanted results to fit his narrative. There seemed to be lots of faith that questionnaires were measuring what they were supposed to, rather than being biased by other differences between participants.
eg of review of psychosocial stuff:
Couple of paragraphs on results I pulled out:
@Dx Revision Watch might be interested in this, as she seems familiar with him:
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