I am afraid I am experiencing my first major “crash.” While my physical symptoms have largely been more benign than my mental symptoms, as of the last month I have experienced a significant crash. I haven’t left the house much in the last month and can barely get out of bed until mid afternoon/early evening. I have been doing series of ketamine infusions and while they have helped, when they wear off my body is left almost paralyzed. Ketamine has been well documented to tamper with many energy pathways- “In silicopathway analyses revealed that several hippocampal pathways including glycolysis/gluconeogenesis, pentose phosphate pathway and citrate cycle are affected, apparent by changes not only in metabolite levels but also connected metabolite level ratios.“ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259990/ (very interesting article for anyone regardless). Reintroduction of ketamine normally helps, but with each infusion my sleep deteriorates terribly and I am left not being able to sleep. There has been speculation about whether or not I have bipolar ii (even before I came down with this illness. I am now 22), but this lack of sleep is not mania and I have never had a manic episode before. Before I ever did a ketamine infusion 1 Benadryl and 1 klonopin would knock me on my ass. Now to sleep I have to take 2 klonopin, 12.5 ambien cr, and 6 benadryl. Am about to do more ketamine however as I haven’t been to class in more than a month and don’t want to have to drop another semester.