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Evening primrose oil and celecoxib inhibit pathological angiogenesis, inflammation, oxidative stress

Discussion in 'Other Health News and Research' started by Ecoclimber, Mar 27, 2014.

  1. Ecoclimber

    Ecoclimber Senior Member

    Inflammopharmacology. 2014 Mar 25. [Epub ahead of print]
    Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1
    El-Sayed RM1, Moustafa YM, El-Azab MF.

    Rheumatoid arthritis is a chronic inflammatory disease characterized by overproduction of inflammatory mediators along with undermined oxidative defensive mechanisms. Pathological angiogenesis was found to play a critical role in the progression of this disease.

    The current study was carried out to evaluate the anti-angiogenic, anti-inflammatory, and anti-oxidant effects of evening primrose oil (EPO), rich in gamma linolenic acid (GLA), either alone or in combination with aspirin or celecoxib, on adjuvant-induced arthritis. Arthritis was induced by subcutaneous injection of complete Freund's adjuvant (CFA) in the right hind paw of male albino rats.

    All treatments were administered orally from day 0 (EPO, 5 g/kg b.w.) or day 4 (celecoxib, 5 mg/kg; aspirin, 150 mg/kg) till day 27 after CFA injection. In the arthritic group, the results revealed significant decrease in the body weight and increase in ankle circumference, plasma angiopoietin-1 (ANG-1) and tumor necrosis factor-alpha (TNF-α) levels.

    Anti-oxidant status was suppressed as manifested by significant decline in reduced glutathione content along with decreased enzymatic activity of superoxide dismutase and increased lipid peroxidation.

    Oral administration of EPO exerted normalization of body weight, ANG-1, and TNF-α levels with restoration of activity as shown by reduced malondialdehyde levels. Moreover, histopathological examination demonstrated that EPO significantly reduced the synovial hyperplasia and inflammatory cells invasion in joint tissues, an effect that was enhanced by combination with aspirin or celecoxib.

    The joint use of GLA-rich natural oils, which possess anti-angiogenic, anti-inflammatory, and anti-oxidant activities, with traditional analgesics represents a promising strategy to restrain the progression of rheumatoid arthritis
    Little Bluestem, NK17 and merylg like this.
  2. alex3619

    alex3619 Senior Member

    Logan, Queensland, Australia
    This is the strategy I used, more or less (I didn't always use antiinflammatories), from 1993 to about 1998, though in recent times I have taken a different track. Omega-6 oils have to be used with caution in ME as they can drive our problems as well as help. I think a typical patient tend to be deficient, but also tends to over-utilize the omega-6 products.
  3. lansbergen

    lansbergen Senior Member

    I do not want to decrease SOD.
  4. maryb

    maryb iherb code TAK122

    isn't that just a response to the CFA?
    Not as part of the response to the trial meds/supps.
  5. lansbergen

    lansbergen Senior Member

    I do not find the article very clear.

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