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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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Endothelial nitric oxide increased in Normal Flow POTs

R

ramakentesh

Senior Member
Messages
534
Hi this may be of interest, a subset of POTS patients that appear to have too much endothelial and neuronal nitric oxide resulting in blood pooling specific to the stomach region. This could potentially explain B12 efficacy in some forms of POTS/CFS as it is a potent scavenger and potential competitor of NO.

http://ajpheart.physiology.org/content/301/3/H704.abstract

Strange thing is, another major subset of POTS seems to have elevated angiotensin and REDUCED neuronal nitric oxide bioavailability.
 
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