Hi again, it's been a while since I've been around here. Not a good year, a lot of new conditions affected me after I started a therapy with who I now know were a pretty irresponsible medical practitioner. So now I've dropped these therapies, I'm back into my research of the things that have helped me for the last years (and after starting these new treatments seemed to stop helping ) I was pretty excited to see cannabinoids show up in the Naviaux paper and I've been looking into it, but the paper itself doesn't give much info, at least not that I know how to interprete. Any of you can provide some more about it? I'm pretty bad at this momment, really dense brainfog and not much mental energy, so this is intended to be a colaborative investigation thread in hope we can figure out what the true role of endocannabonoids is in ME/CFS. In case you don't know about endocannabinoids or endocannabinoid system here you've got some explanatory resources about it: https://www.leafly.com/news/science-tech/what-is-the-endocannabinoid-system https://en.wikipedia.org/wiki/Endocannabinoid_system There are plenty of exciting articles about endocannabinoids' role and pharmacological potential in pubmed, I'm sure a lot of the more ilustrated PR users will be able to find the most related to the ME/CFS pathology. This is an unexplored therapeutic path that we cannot leave behind, lots of Fibromyalgia sufferers already bennefit from the endocannabinoid regulation through cannabis, maybe cannabis is not the solution for ME/CFS but there are other ways to interact with the endocannabinoid system.