emtracitabine, a reverse-transcriptase inhibitor (anti retroviral med)

[Rrrr]

emtracitabine, a reverse-transcriptase inhibitor (anti retroviral med)

since the NIH/FDA/Harv paper came out, i have now heard the drug emtracitabine used twice.

here it is in the ME Assoc statement:
http://www.forums.aboutmecfs.org/sh...Summary-amp-Statement-on-Lo-Alter-et-al-Paper

"The MEA has already pointed out on several occasions that this type of clinical trial would have to proceed with great care given the fact that ARTs can have serious side-effects. In the case of AZT, this drug can cause mitochondrial damage - which is obviously very relevant in ME/CFS. But there are other ARTs becoming available that appear to be active against XMRV and may be much safer to use (eg reverse-transcriptase inhibitors such as tenofovir and emtracitabine)."

this medicine/drug, emtracitabine, was not mentioned in singh's paper on what meds stunted XMRV in the test tube (paper found here: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009948). that paper found that AZT,
Raltegravir (Isentress), Tenofovir (Viread) helped stunt xmrv growth.

Does anyone know anything about emtracitabine?

 

[Rrrr]

I JUST SENT THIS EMAIL TO THE AUTHOR OF THE COMMENTARY PAPER.

Hi Dr. Mason,

Thank you 100 times for your commentary on the NIH/FDA/Harv paper. As a patient for 20 yrs who has spent much of that time bedridden and homebound, I feel your suggestion of clinical trials as a viable option is right on.

I am writing with a follow up question: How you came to include emtracitabine as a possible antiretroviral for this family of viruses?

I ask because I see that it was not found effective in Dr. Singh's paper on what meds stunted XMRV in the test tube (paper found here: http://www.plosone.org/article/info:...l.pone.0009948). Singh's research found that AZT, Raltegravir (Isentress), Tenofovir (Viread) helped stunt xmrv growth, but emtracitabine did not.

I am eager to hear your thinking.

MUCH APPRECIATION FOR ALL YOU HAVE DONE!

 

[acer2000]

In the Singh paper they also mention the compound " L-000870812" which appears to be another integrase inhibitor like Ral. Does anyone know anything about this one as well? Maybe it has better CNS penetration than Ral?

 

[Daffodil]

yes that drug works well on XMRV but it is still in clinical trials..not sure which phase

 

[SickOfTheSickness]

this medicine/drug, emtracitabine, was not mentioned in singh's paper on what meds stunted XMRV in the test tube

Hi,

it actually was tested in Singh's study and found to be not working for XMRV. See Fig. 1 of that study http://www.plosone.org/article/slid...RI=info:doi/10.1371/journal.pone.0009948.g001

Regards
Andreas