This is just superficial, anecdotal, early, and possibly unsubstantiated, but maybe these are early evidence possible response to equilibrant. I started the titration procedure to begin Equilibrate about a month ago. I am now on two tablets per day. Recent changes are: My sore throat came back since I saw Dr. Chia. However, it has recently reduced in intensity by about 30-50%. Maybe that is interesting. My poop has been somewhat normal shaped for the last few days. Usually it is mushy. Something changed about my sleep, but I'm not sure what exactly it is. It is still generally poor, but it seems to have changed slightly. Of course these are minor and anactotial things that may indicate nothing except the cyclical nature of CFS/ME. but there is a small chance that these are early indicators of responding to Equilibrant.