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Drinking baking soda (sodium bicarbonate) may treat autoimmune disease

Discussion in 'General Treatment' started by Hip, Apr 26, 2018.

  1. Hip

    Hip Senior Member

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    A new study found that a daily dose of baking soda (sodium bicarbonate) may help reduce damaging inflammation in autoimmune diseases:

    Oral NaHCO3 Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted via Mesothelial Cells. Full text here.

    In the study, healthy human subjects were given 2 grams of sodium bicarbonate dissolved in 250 ml of bottled water. The study found this oral sodium bicarbonate consumption:
    • Activates splenic anti-inflammatory pathways in both rats and humans
    • Increases the size of the spleen over time
    • Shifts macrophage polarization from M1 (inflammatory) to M2 (regulatory) phenotypes
    • Increases FOXP3 CD4 regulatory T-cells (FOXP3 T-regs) in the spleen, blood, and kidneys
    FOXP3 T-regs have been shown to be beneficial in a wide range of conditions, including allergy, asthma, multiple sclerosis, diabetes and hypertension.

    The authors speculate that the anti-inflammatory effects of oral sodium bicarbonate arises by activation of the cholinergic anti-inflammatory pathway, and that mesothelial cells (which line the body's internal organs and serous cavities) may have a role in this process.

    It was found mesothelial cells have little fingers called microvilli which sense the environment and warn the organs when an immune response is needed to fight a microbial invader. Drinking sodium bicarbonate tells the spleen to go easy on the immune response.



    Note that sodium bicarbonate is best taken away from meals, otherwise it may partially neutralize the stomach acid needed to digest food.

    Taking a high dose of sodium bicarbonate on a regular basis will have an alkalizing action on the body. I get a little lightheaded when I am on an alkalizing diet, and that helps me gauge the alkalizing action. I find as little as 4 grams of sodium bicarbonate each day is enough to create via alkalizing this lightheaded feeling.

    Note:
    One level teaspoon of sodium bicarbonate = 4 grams
    One heaped teaspoon of sodium bicarbonate = 12 grams



    Some articles about this study:
    Drinking baking soda safe therapy for autoimmune disease – study
    Drinking baking soda could be an inexpensive, safe way to combat autoimmune disease: study
     
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  2. Learner1

    Learner1 Forum Support Assistant

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    Fascinating! Thanks for sharing!

    How exactly do you do this? I eat and take supplements all day long... What exact timing after one meal and before the next do you think would work?

    I've read about acid/alkaline diets and the negative is the body's tendency to correct for changes to promote homeostasis... so any intervention will be adapted to.

    And, do the constituents of one's microbiome care about how acid or alkaline it is? Would it make a difference in the microbiome over time?

    Anyway...very thought provoking!
     
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  3. Hip

    Hip Senior Member

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    I would think say 45 minutes before a main meal or snack might be fine; but I would wait 2 hours after a main meal before taking bicarb.
     
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  4. Wonkmonk

    Wonkmonk Senior Member

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    Could this be helpful for allergies, too?
     
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  5. alex3619

    alex3619 Senior Member

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    Interesting research, I hope it is followed up.
     
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  6. pamojja

    pamojja Senior Member

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    Do you know if sodium bicarb taken together with ascorbic acid in water (which changes both to sodium ascorbate, the carbon dioxide fizzling away) on an otherwise empty stomach could still have the same benefits?

    Chemically it seems unlikely, though my experience taking high dose vitamin C this way seems to suggest. Since with all my blood-gasses analysis the blood pH came back highly alkaline (7.48; 7.35 - 7.45 pH normal range). Also sodium bicarb is considered by some an uranium chelator, which would explain in my case why I had a sudden rise above normal for uranium in HTMA, declining short after again after starting with higher bicarbs (~2.5 g/d; sodium and potassium). My spleen is a bid enlarged too.
     
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  7. tiredowl

    tiredowl

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    Would this be safe though? I mean lowering stomach acid doesn't seem like a good idea, especially if you don't want to get sick from viruses and stuff.
     
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  8. Ema

    Ema Senior Member

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    I think you actually get a rebound acidification because the body senses the alkaline state. That’s why they always say to do it between and before meals so that when you eat, it takes advantage of the higher acid levels.

    This is all what I remember of various internet lore around baking soda. If someone has science saying otherwise, by all means.
     
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  9. tiredowl

    tiredowl

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    Ah, thanks. Maybe this could be something worth trying. Doesn't it also affect lactic acid?
     
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  10. rel8ted

    rel8ted Senior Member

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    Interesting, @Hip.
    I've had my hub on a lower dose of baking soda for about a year now, old timers used to use it for high blood pressure. He says he thinks it has helped his digestion as well. He's not off his HBP meds, but no longer feels the effects of them not being as effective a few hours before the next dose. He's taking 1/2 tsp every morning, first thing.
     
    Last edited by a moderator: Apr 28, 2018
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  11. Hip

    Hip Senior Member

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    I am guessing it might be useful for allergies, as the paper says that the FOXP3 T-regs that are up-regulated by sodium bicarbonate are helpful for allergies, asthma, multiple sclerosis, diabetes and hypertension.



    Stomach acid is created on demand by the parietal cells in the stomach wall when required. If you neutralize this gastric acid with bicarbonate, some more will be produced when needed.

    Incidentally, it is the parietal cells of the stomach that are found to be infected with chronic non-cytolytic enterovirus in patients with enterovirus-associated ME/CFS (see Dr John Chia's study). I wonder whether such infected parietal cells might be the cause of the low stomach acid levels that some ME/CFS patients like myself anecdotally report using the (unvalidated) bicarbonate burp test for stomach acidity level.



    It will still have the same benefits as far as vitamin C status is concerned, since sodium ascorbate is still a usable form of vitamin C; but once you have neutralized the alkalinity of sodium bicarbonate by reacting it with ascorbic acid, I would doubt the bicarbonate will still have this anti-autoimmune and anti-allergy effect.



    Yes, some people have found that sodium bicarbonate helps reduce their PEM (see the PEM busters thread), presumably because it neutralizes lactic acid.



    That's a good question. I could not find much info on this when I Google search: alkalizing diet microbiome.

    Normally, gastric acid secreted in the stomach to digest food is later neutralized anyway, as the food passes through the duodenum (the body secretes sodium bicarbonate in the duodenum to achieve this neutralization).
     
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  12. MartinK

    MartinK

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    Interesting! thanks @Hip

    Im interested in this use in connection with leaky gut/SIBO - no problem?
    Id like to test it, but Im on leaky gut/SIBO treatment with Normix and Mesalazine.

    Is sodium bicarbonate OK with this treatment?
     
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  13. Hip

    Hip Senior Member

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    I would not have thought that sodium bicarbonate will interfere with your treatment.
     
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  14. researcher

    researcher

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    I thought this was standard practice among people with CFS... I do this every single day...
     
  15. WendyM

    WendyM

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    @Hip, thanks for this great information.

    In the articles which summarise the J. Immunology article, it says ..

    “That anti-inflammatory shift was sustained for at least four hours in humans and three days in rats.” (Punch).

    This would seem to indicate that a dose of sodium bicarb should be spread at four hourly intervals throughout the day. Yet the students used in the study were given a once daily dose of 2gms, which produced the anti inflammatory response.

    I have two autoimmune problems (Hashimotos and Autoimmune Adrenal Disorder) and the expected high level of inflammation in my body, so am very interested. I have been taking sodium bicarb spasmodically after I found it improved my energy after taking some for a bladder infection. I would like to take it now on a regular basis, but would find it difficult to manage on a four hourly intervals. I’d be able to manage two doses, mid morning and mid afternoon.

    How frequently do you take it?

    Thanks,

    Wendy
     
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  16. Hip

    Hip Senior Member

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    Even taking just one 2 gram dose of sodium bicarbonate daily is going to have an alkalizing effect on the body; I think if you took a 2 gram dose every 4 hours — which would amount to 8 grams per day — that would have a strong alkalizing effect. I am not sure what the safe maximum daily dose of bicarbonate is, but at higher doses I think you would want to watch out for metabolic alkalosis.
     
    Last edited: Apr 30, 2018
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  17. Cipher

    Cipher

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    Examine.com has a great page on sodium bicarbonate:

    One thing that I've read but can't remember where is that one should avoid taking high doses of both bicarbonate and calcium carbonate because it could cause milk-alkali syndrome.

    It may be prudent to take Vitamin K alongside bicarbonate if taken chronically to minimize the risk of arterial calcification, because removing an eventual mild acidosis can theoretically increase the risk. I've read a lot about sodium bicarbonate in the context of CKD.
     
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  18. Hip

    Hip Senior Member

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    Very useful info @Cipher. So for an 80 kg person, a total daily dose of around 16 to 24 grams of sodium bicarbonate is safe, according to the Examine.com article, if used before exercise.

    I wonder what the safe daily dose is in people not performing exercise.
     
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  19. pamojja

    pamojja Senior Member

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    examine.com says "Some health effects (increase in metabolic rate or attenuation of metabolic acidosis) can be achieved at more reasonable doses, such as 5-10g, and may be more practical for nonathletes." Didn't see a source for that quote.

    It really is confusing. Not only because of my experience of bicarbonates with ascorbic acid alkalizing my blood. But allegedly even taking it with food - at which time the bicarbonate should be definitely neutralized by the much higher acidity of stomach acid compared to ascorbic acid - it nevertheless seems to turn out alkalizing even more?!?

     
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  20. mariovitali

    mariovitali Senior Member

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    @Hip

    Great info there, Thank you.


    FOXP3 may deserve more attention.
     
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