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Does LDN lose it's effectiveness over the long term?

Discussion in 'General Treatment' started by BrianD15, Sep 17, 2017.

  1. BrianD15

    BrianD15

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    LDN is one of the treatments that I started on pretty quickly after being diagnosed with CFS. When I first titrated up to the 4.5mg dose I felt absolutely amazing. My sleep was incredibly refreshing, my brain fog was gone, I was very energetic and motivated, and at work I was really engaged and practically dancing while working at the computer. Over time the effects became less obvious though. Now two years later I continue to take it, but it's not clear that it gives me any benefits. If I miss a dose, or even if I take a break for a whole week, I don't notice any difference. My doctor still seems to think that it's important that I stay on it though.

    What are your experiences? Does it still seem like a clear win to you?
     
    sb4 likes this.
  2. Hip

    Hip Senior Member

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    sb4 likes this.
  3. *GG*

    *GG* senior member

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    Concord, NH
    I started LDN in late 2009 stopped about 1 year ago. Insurance changed so not covered, just don't have the cash to pay out of pocket. I have not noticed a decline, yet, would probably get back on it in the near future. Guess when I take LDN again, could be interesting to see what happens :)

    GG
     
  4. BrianD15

    BrianD15

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    Yeah, I wonder if having enough time off the drug before restarting would enable me to experience the initial euphoria again. I took a week off on two different occasions without any noticeable effect when I restarted, so that was clearly not enough time.
     
  5. adelheid55

    adelheid55 Senior Member

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    I'm on LDN for a year now. It doesn't take all muscle pain away a but it's really tolerable. And when I sometimes do too much I find myself in pain again. That's not a bad thing because I then know how much LDN helps me.
    So for me it still works.
     
    Last edited: Sep 18, 2017

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