Inositol is sometimes referred to as a methyl donor. I do well with methyl donors like MB12, methylfolate, SamE, and DMG, which encourage the methionine synthase flow, per Rich V’s recommendations. I feel worse on BMHT agents like TMG and choline. So before trying it, I’d like to know which pathway inositol works on. Freddd has stated that inositol might increase the need for methylfolate, much like excess niacin. But even Freddd is not always right on. Please fill me in if you know anything. Thanks.