New Atmosphere, New Vision: Gibson and Whittemore Kick Off Invest in ME Conference 2016
Mark Berry reports on Dr. Gibson's introduction and Dr. Whittemore's keynote speech, at the 11th Invest in ME International ME Conference in London.
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Does folate/B12 raise cortisol?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Ninan, Jun 13, 2016.

  1. Ninan

    Ninan Senior Member

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    My saliva cortisol test showed higher cortisol the hours after taking methyl folate. Why is that? Has enoyone else noticed this correlation? Does it stimulate adrenals or does it just help HPA signalling? According to 23andME I'm a bit sensitive to methyl groups but different kinds of folate always had the same effect on me, no difference between them.

    My adrenals seem very weak at the moment and I've started crashing the day after having effect from metafolin. Is cortisol the reason it gives energy?

    This study found a correlation: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847740/

    Could folate be bad for adrenals?
     
    Last edited: Jun 13, 2016
  2. PeterPositive

    PeterPositive Senior Member

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    The study you have posted used a multivatimin that has all th B complex, plus antioxidants and other botanicals.

    In the discussion sections they say:
    It's a quite difficult to isolate the effects of B12/B9 from the study...

    You mention having taken Metafolin... is it the first time you've tried it? What dosage? Do you also take B12 with it?

    cheers
     
  3. Ninan

    Ninan Senior Member

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    Ok, thanks Peter. I've taken it for years. Have had problems with C so had to stop for some time. Took some pig liver and had effect but crashed the fifth time. From just maybe 10-20 grams of liver. I seem to have quite strong folate effect from liver.

    Maybe it's just a bit too stimulating when my adrenals are this bad.
     
  4. Ninan

    Ninan Senior Member

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    I'm thinking of trying hydroxycobalamin. Maybe the combination folate (other kind?) and hydroxy could be milder on the adrenals.
     
  5. Critterina

    Critterina Senior Member

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    Arizona, USA
    Your saliva cortisol should be higher in the morning. In the study, they only measured it in the morning. It's not like they gave it to them at different times of day and then measured cortisol shortly after. But in the study what they found was that it was higher when they'd been supplementing for a while - after 8 and 16 weeks, not a measurement immediately after taking the supplements.

    That's how it's supposed to work, being higher in the morning. If it's low, or if you have symptoms of low adrenal function, see if the doctor will give you a short cosyntropin test (a.k.a ACTH stimulation test), to see whether your adrenals have the ability to respond properly to stress.

    It's my feeling that if you are having symptoms of low adrenal function (buzzy body, insomnia, hypoglycemia, extreme weakness, dizziness, nausea, fainting, nightly bilateral pain in the kidney areas) you're close enough to crisis to either have the test or go to the emergency room. My endocrinologist said I was fine and referred me to the Mayo Clinic. Let me save you that runaround - the Mayo clinic does not have any doctors who see or treat people for adrenal insufficiency. And they repeated that when I told them that I didn't have that diagnosis, that my doctor said I was fine.

    Now, as to whether the vitamins help your adrenals recover, I don't know - the study was done with healthy adults. But that said, I just had my morning serum cortisol measured and it was nearly twice what it was last year (after being low since 2012). It can double again and still be normal, but I'm taking credit for progress.

    Also, many doctors don't take a saliva test as diagnostic for low cortisol, only for high cortisol; they say you have to have morning blood test to determine low cholesterol. It's not universal, but I've run into it.
     
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  6. Ninan

    Ninan Senior Member

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    Thanks @Critterina My cortisol is low all over, except when I take folate. Trying adrenal extracts now.
     
  7. Critterina

    Critterina Senior Member

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    Well, that's really interesting. I have no idea how that works. I wonder if overall if the folate is helping my adrenals come back, in terms of cortisol.
     

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