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Do you have zonulin test?

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by quasar, Apr 8, 2017.

  1. quasar

    quasar

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    If you have, what is the result? Is it accurate, reliable? I could not understand, how leaky gut is detected by checking blood? Do results depend on what we eat in two days?
     
    Last edited: Apr 8, 2017
  2. ljimbo423

    ljimbo423 Senior Member

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    From what I understand, a blood test can show your zonulin levels. If they are high, that means you could have a leaky gut. Zonulin opens up the spaces between the cells in your gut, causing a leaky gut. SIBO (small intestinal bacterial overgrowth) is one thing that can raise zonulin levels. Here is a link to a functional medicine doctor, that explains zonulin in great detail.
     
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  3. Thinktank

    Thinktank Senior Member

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    I have zonulin tested in faecal sample, it's elevated.
     
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  4. kangaSue

    kangaSue Senior Member

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    http://fg.bmj.com/content/early/2016/03/07/flgastro-2015-100651
    [Increased intestinal permeability (IP) has also recently been associated with syndrome-defining symptoms of IBS, and has been detected in mucosa of patients with IBS.35 Zonulin is a peptide signalling molecule that disrupts tight junctional proteins between intestinal mucosal cells, leading to increased intestinal permeability (IIP).36 Serological testing for zonulin has been demonstrated to correlate well with gold-standard lactulose/mannitol testing in patients with increased IP from several causes (R2=0.7935).37 A recent study, published to date in abstract form only, has demonstrated elevated blood zonulin levels in subjects with IBS-D.38]
     
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  5. JollyRoger

    JollyRoger Senior Member

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    I made a zonulin test. I tested it with a home test kit from Amazon (Germany).
    It was slightly elevated so I will give the gluten/diary diet a try and a daily dose of glutamin.

    Do you think it could be responsible for cfs?
     
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  6. Silence

    Silence

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    Had it done too by KDM. Mine was elevated. I have been dealing with chronic Diarrhea for many years now. How many with elevated zonulin have IBS-D? or some form of gut dynfunction?
     
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  7. Hip

    Hip Senior Member

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    What is the accuracy of the zonulin test is, compared to the standard tests for leaky gut, such as the lactulose/mannitol test and the polyethylene glycol test?

    Why would someone take a zonulin test, instead of the lactulose/mannitol test which directly measures gut leakiness?
     
    Last edited: Jun 2, 2017
  8. Thinktank

    Thinktank Senior Member

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    Gluten can certainly raise zonulin, but so can certain intestinal bacteria.
    My zonulin levels did not decrease significantly after being 6 months gluten free, so in my case it's probably intestinal bacteria or something else raising zonulin.
     
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  9. JollyRoger

    JollyRoger Senior Member

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    Aha... and how can we destroy them; or should we destroy them???
     
  10. kangaSue

    kangaSue Senior Member

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    Are you asking about intestinal bacteria? Out compete them with a Fecal Transplant!
     
  11. JollyRoger

    JollyRoger Senior Member

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    Do I have to restore the leaky gut before a transplant?
    First eradicating the old flora with antibiotics?
    DIY or professional?
     
  12. kangaSue

    kangaSue Senior Member

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    Ulcerative Colitis is something with anecdotal evidence of having success with FMT and it's impossible to first stop a leaky gut if you have that so I would say not.

    Not many countries allow even professionals to use FMT other than for C diff. It's accessible here in Australia for things other than C diff, a standard protocol is antibiotics then a colonoscopy prep purge followed by up to ten FMT treatments, at a cost though, around A$13,000 last time I inquired.

    The choice of whether or not to go d.i.y is up to you.
     

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