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Disulfiram for persistent forms of Borrelia burgdorferi

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by paolo, Dec 14, 2016.

  1. paolo

    paolo Senior Member

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    I have recently watched a conference about Lyme disease held in October at Icahn School of Medicine at Mount Sinai (New York). During the conference, prof. Kim Lewis (Northeastern University) talked about the persistent phenotype of Borrelia burgdorferi as a possible cause for at least some cases of post-treatment Lyme disease syndrome (PTLDS). He mentioned a drug (disulfiram) as a possible treatment for this condition. Disulfiram has been studied for Lyme disease only in vitro, so far (Pothineni V et al. 2016), but Kim Lewis mentioned a trial on the animal model of Lyme borreliosis, which is ongoing. You can follow his lecture in this video (from 39:00) and in this one (from 7:00). It is currently unknown how disulfiram exerts its action on Borrelia burgdorferi, but we know that in vitro it is able to kill persistent forms.

    My question is: has any of you tried this drug? It is curently used against alcoholism, as it is an inhibitor of the enzyme acetaldehyde dehydrogenase and thus it lets acetaldehyde build up, if you drink any alcohol, leading to unpleasent consequences.
     
    Last edited: Dec 14, 2016
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  2. roller

    roller wiggle jiggle

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    you may take any other poison as well.

    its old news that poisons do help.
     
  3. Hip

    Hip Senior Member

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    Disulfiram is mentioned in this paper which searched for anti-Borrelia compounds.
     
  4. paolo

    paolo Senior Member

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    Yes, it is the paper I cited above. it is the in vitro study.
     
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  5. Mel9

    Mel9 Senior Member

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    Very interesting. Also see the New thread discusses this: 'documentary, undercover in german lyme clinics'
     

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