I am on round three of methylation using Freddd's supplements plus magnesium Vit c and others. The first tow times I tried this I really noticed improvement, and last year I was potentially worse off before. Now, I am getting a lot of weird side effects , especially feeling really tired at times, and a seeming up and down neurotransmitter/hormone balance. This popped up slightly the last time I tried this, but not nearly as strong. Last time I was tested (Aug of last year) my cortisol was supposedly normal, and as far as I know, thyroid, and adrenal is not an issue. On the other hand, this could just be undetected and in need of testing.