New Atmosphere, New Vision: Gibson and Whittemore Kick Off Invest in ME Conference 2016
Mark Berry reports on Dr. Gibson's introduction and Dr. Whittemore's keynote speech, at the 11th Invest in ME International ME Conference in London.
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Diary-based outcome predictors in a selfmanagement trial in chronic fatigue syndrome

Discussion in 'Latest ME/CFS Research' started by Dolphin, Feb 7, 2017.

  1. Dolphin

    Dolphin Senior Member

    Main findings:

    Woolie, Mel9, Valentijn and 1 other person like this.
  2. RogerBlack

    RogerBlack Senior Member

    Interesting. We need more of this type of thing.
    I need to dig into it tomorrow to see if they mention PEM duration and factors and percentage 'recovery' and thresholds.
    Valentijn likes this.
  3. trishrhymes

    trishrhymes Senior Member

    Has anyone got a link so we can read the whole paper. I confess I don't really understand the research from this summary. When I see a statement like

    'clinically significant fatigue change at 12-month follow-up was predicted by these diary variables (assessed at intervention termination): positive changes in enjoyment (r = .50; p = .02), less activity difficulty (r = .53; p = .02)'

    it sounds to me like a statement of the bleedin' obvious - if you're less fatigued, you're more likely to enjoy things, and if you're finding activity less difficult isn't that just another way of expressing the fact that you're less fatigued...

    I wonder what fatigue measure they used. If it was Chalder Fatigue Scale, the whole thing is a non starter, since it doesn't measure degree of fatigue.

    And were any objective measures used - actometers, heart rate monitors, step tests, walking tests, ...

    And what diagnostic criteria did they use for recruitment to the trial? Did they record episodes of PEM, etc etc. And what was the sample size? The p values quoted are not strongly significant, so if it's a small sample with no objective measures and poor quality questionnaire measures, it's a non starter as far as I'm concerned.
    TiredSam likes this.
  4. AndyPR

    AndyPR Senior Member

    trishrhymes likes this.
  5. Woolie

    Woolie Senior Member

    Yea, this smells of the usual confusion of causation and correlation.

    I bet these authors never go to hospital - admission into a hospital is a major predictor of imminent death!
  6. trishrhymes

    trishrhymes Senior Member

    Thanks for the link, Andy.

    It's very confusing - they say it's a study of severely affected patients, then talk about 'pacing at work', and walking as a helpful form of exercise. Surely if a person is severely affected they can't possibly be working, and walking is likely to be severely curtailed.

    And why on earth no objective tests? I see it's a New York based study. I would have hoped for better.

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