Lipkin's Monster ME/CFS Study: Microbes, Immunity & Big Data
The Microbe Discovery Project outlines an ambitious new study by top researchers that has collected patient samples, but needs desperately funds to complete the work.
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Diagnosis of Myalgic Encephalomyelitis: where are we now? Maes M, et al.

Discussion in 'Latest ME/CFS Research' started by snowathlete, Mar 14, 2013.

  1. snowathlete




    Introduction: The World Health Organization has classified Myalgic Encephalomyelitis (ME) as a neurological disease since 1969 considering Chronic Fatigue Syndrome (CFS) as a synonym used interchangeably for ME since 1969. ME and CFS are considered to be neuro-immune disorders, characterized by specific symptom profiles and a neuro-immune pathophysiology. However, there is controversy as to which criteria should be used to classify patients with "Chronic Fatigue Syndrome." Areas covered: The Centers for Disease Control and Prevention (CDC) criteria consider chronic fatigue (CF) to be distinctive for CFS, whereas the International Consensus Criteria (ICC) stresses the presence of post-exertion malaise (PEM) as the hallmark feature of ME. These case definitions have not been subjected to rigorous external validation methods, for example, pattern recognition analyses, instead being based on clinical insights and consensus. Expert opinion: Pattern recognition methods showed the existence of three qualitatively different categories: (a) CF, where CF evident, but not satisfying full CDC syndrome criteria. (b) CFS, satisfying CDC criteria but without PEM. (c) ME, where PEM is evident in CFS. Future research on this "chronic fatigue spectrum" should, therefore, use the abovementioned validated categories and novel tailored algorithms to classify patients into ME, CFS, or CF.
    taniaaust1, Simon and Valentijn like this.
  2. Simon


    Monmouth, UK
    think that's exactly right. Hopefully the large CDC clinical study under way gathering info on large numbers of patients from Klimas, Peterson etc will allow such pattern recognition studies to take place on a large scale. Then we can have a face-off between CDC, CCC & new ICC criteria. Should be interesting.
    snowathlete likes this.

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