Star-Anise
Senior Member
- Messages
- 218
@Radio Awesome! Thanks so much. I have some reading to do... S
Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
To become a member, simply click the Register button at the top right.
OK, Where do we go from here, How do we fix this metabolic dysfunction?
The main cause of the metabolic dysfunction is the weak break down of tryptophan. We know quinolinic and interferon gamma are elevated and need to be reduced. The key factor is the NAD+ deficiency, as well as the NADH recycling, anaerobic metabolism imbalance. Ok, How do we fix this?
The best approach would be to eat a low animal protein diet to compensate for the build up of quinolinic and interferon gamma from the lack of tryptophan conversion. The next step would be to supplement with either Free form Tryptophan, Nicotinamide, NAD+ or NADH with R- lipoic acid to compensate for the NAD+ deficiency. Riboflavin is needed for the monoamine oxidase enzyme, which functions in this metabolism. This could be the solution to the metabolic dysfunction and the missing link to CFS/ME.
Just to play devil's advocate here:
...
2) Do we really want to be supplementing large doses of tryptophan? Some of that converts to serotonin and would strongly affect many other systems not just NAD+ production? Also, if we have a failure to convert tryptophan, how would supplying more tryptophan fix that?
3) NADH is probably the one supplement you would NEVER want to take, The whole point of this paper was that the NADH is piling up in your body and is not able to convert back to NAD. As a result, the mitochondria are processing it in some very bad way that creates lots of free radicals. It would not only not solve the NAD+ problem to take NADH, but you would actually be making the damage to your body significantly worse, by increasing free radical production.
...
5) It seems to me the key recommendation should be for niacinimide, NMN (used in David Sinclair's mouse study), or Niagen / Nicotinamide Riboside (NR). I have read that NMN and NR may promote cancer so you use them at your own risk. What about niacinimide? I read one source that claimed studies show it is not only safer, but generates 20%+ more NAD+ conversion? I have yet to locate the original sources on this claim.
Point number 5) deserves its own thread. I can't believe this is not being discussed every day on this site. To me this looks like something very close to a potential cure.