deciphering

[D2311]

I ran the analyzemygenes program and found the following results and am wondering where to start.​

 

[D2311]

methylation results from 23 and me
COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CT +/-
VDR Taq rs731236 AG +/-
MAO-A R297R rs6323 TT +/+
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AG +/-
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 GT +/-
MTR A2756G rs1805087 AA -/-
MTRR A66G rs1801394 GG +/+
MTRR H595Y rs10380 __ no call
MTRR K350A rs162036 AA -/-
MTRR R415T rs2287780 __ no call
MTRR A664A rs1802059 AA +/+
BHMT-02 rs567754 CC -/-
BHMT-04 rs617219 __ no call
BHMT-08 rs651852 CC -/-
AHCY-01 rs819147 TT -/-
AHCY-02 rs819134 __ no call
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 GG -/-
CBS A360A rs1801181 AG +/-
From what I have been reading the combination of the COMT homo mutations along with mao and mtrr can cause compounding effects. My symptoms are heavy brain fog at times, rollercoaster moods, fatigue, inflamatory issues.
I have felt hung over every morning when I wake up for over 25 years.

 

[D2311]

and Detox results which I am finding less information the the mthfr
CYP1A1*2C A4889G rs1048943 TT -/-
CYP1A1 m3 T3205C rs4986883 TT -/-
CYP1A1 C2453A rs1799814 GG -/-
CYP1A2 164A>C rs762551 AC +/-
CYP1B1 L432V rs1056836 GG +/+
CYP1B1 N453S rs1800440 TT -/-
CYP1B1 R48G rs10012 CC +/+
CYP2A6*2 1799T>A rs1801272 AA -/-
CYP2A6*20 rs28399444 II -/-
CYP2C9*2 C430T rs1799853 CC -/-
CYP2C9*3 A1075C rs1057910 AA -/-
CYP2C19*17 rs12248560 CT +/-
CYP2D6 S486T rs1135840 CG +/-
CYP2D6 100C>T rs1065852 GG -/-
CYP2D6 2850C>T rs16947 AG +/-
CYP2E1*1B 9896C>G rs2070676 CC -/-
CYP2E1*1B 10023G>A rs55897648 GG -/-
CYP2E1*4 4768G>A rs6413419 GG -/-
CYP3A4*1B rs2740574 TT -/-
CYP3A4*2 S222P rs55785340 AA -/-
CYP3A4*3 M445T rs4986910 AA -/-
CYP3A4*16 T185S rs12721627 GG -/-
GSTP1 I105V rs1695 AG +/-
GSTP1 A114V rs1138272 CC -/-
SOD2 A16V rs4880 GG +/+
NAT1 R187Q rs4986782 GG -/-
NAT1 R64W rs1805158 CC -/-
NAT2 I114T rs1801280 TT -/-
NAT2 R197Q rs1799930 AG +/-
NAT2 G286E rs1799931 GG -/-
NAT2 R64Q rs1801279 GG

 

[Valentijn]

I ran the analyzemygenes program and found the following results and am wondering where to start.

It can help to also download and unzip remarks.zip and ten_percent.zip from https://sourceforge.net/projects/analyzemygenes/files/Databases/ . Then it will label genes and mutations if you run it again.

rs35667974 is a missense mutation on IFIH1, which might be interesting as it involves immune reactions. But the substituted amino acid is nearly identical.

rs17078894 is a missense mutation on GRM6, a glutamate receptor gene.

rs41549716 is a missense mutation on POLG. It's a very different amino acid substitution, so might impact the protein's functionality. But usually mutations on this gene only cause problems if homozygous.

 

[D2311]

So the double COMT ++ and MAO are my biggest suspects. I went to a naturopathic doctor to try a new approach. She ordered a lot of tests and here were the things that stuck out

hemoglobin alc high
Thyroid high reverse T3
high LDL-P
High homocycstene
Low WBC
Low D even though I supp. 2000 units
High Zinc, weird as I take none
High AG ratio

also had some neuro tests
low PEA
low Dopamine
very low Norepinephrin
low epinephrine
the adrenaline surprised me as the COMT++ is supposed to slow the breakdown of these. I am wondering if its a negative feedback thing, or adrenal fatigue.

Doc has recommended
L tyrosine
enzymes Panplex
D3 20,000 a day
and berberine for cholesterol

Id love to hear anyone elses thoughts on these results, and recommended treatment.