Day Seven on LDN

[mobetterblues]

Ok

That might be the endorphin blocking effect but it's supposed to wear off within a few hours once the body makes more endorphins. It's one of the reasons why it's usually recommended to take LDN at night, so that a person can sleep through the potentially depressive low-endorphin period.

Fatigue is very common. More info is available on Dudley's LDN site:
Potential side effects of LDN
Drugs to avoid while taking LDN

that's very helpful information- I think because I am weaning off tramadol that there is some of that happening- ok, thanks for that! I'll check the link too

 

[panckage]

@mobetterblues: ! I had to stop the LDN altogether for a week, because I pulled a tendon and had to take pain meds for about three days.

Just so you know you can still take pain meds (opiods) while taking LDN with 2 caveats
1) If you are start taking LDN while on opiods, it is similiar to quitting the opiods cold turkey (maybe worse)
2) taking LDN after taking an opiod will nullify the effect of the opiod for the 4 hours or so the LDN is active. If you take an opiod outside of this 4 hours it works fine (and even has a positive - see below)


Some pluses as well
1) LDN reduces tolerance to opiods. In fact there is a painkiller that contains both LDN and an opiod for that very reason
2) Marijuana has a more intense effect while on LDN. Supported both by research and personal experience

 

[mobetterblues]

Just so you know you can still take pain meds (opiods) while taking LDN with 2 caveats
1) If you are start taking LDN while on opiods, it is similiar to quitting the opiods cold turkey (maybe worse)
2) taking LDN after taking an opiod will nullify the effect of the opiod for the 4 hours or so the LDN is active. If you take an opiod outside of this 4 hours it works fine (and even has a positive - see below)


Some pluses as well
1) LDN reduces tolerance to opiods. In fact there is a painkiller that contains both LDN and an opiod for that very reason
2) Marijuana has a more intense effect while on LDN. Supported both by research and personal experience

Thank you! I've noticed I need less and less tramadol- and if I do take more than needed I get a 'woooaa' feeling- like my eyes get super sleepy and i just feel it too much-
What is the painkiller that combines both?

I already have a gigantic reaction to any marijuana without any extra 'fun' stuff, so I'd probably end up running he streets naked laughing my ass off if I tired both together
But just For knowledge sake, what is the reaction for you?

 

[panckage]

What is the painkiller that combines both?

Good question... I have been unable to relocate the medication. Actually while the naltrexone may have been added to reduce tolerance it is also possible that the naltrexone was added as an antitemper mechanism (eg. Crush the pill and the naltrexone will precipitate withdrawal) . Unfortunately I don't remember which one it was.

Here's a study though that talks of using naltrexone to reduce tolerance... in my head smaller doses than we use though:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657183/

It sounds like you would have fun using marijuana and naltrexone together haha. I think i feel more shaky and like I vaped more marijuana when taken together

 

[belize44]

Just so you know you can still take pain meds (opiods) while taking LDN with 2 caveats
1) If you are start taking LDN while on opiods, it is similiar to quitting the opiods cold turkey (maybe worse)
2) taking LDN after taking an opiod will nullify the effect of the opiod for the 4 hours or so the LDN is active. If you take an opiod outside of this 4 hours it works fine (and even has a positive - see below)


Some pluses as well
1) LDN reduces tolerance to opiods. In fact there is a painkiller that contains both LDN and an opiod for that very reason
2) Marijuana has a more intense effect while on LDN. Supported both by research and personal experience

Yes, I thought that since I was taking such a low amount of LDN, that it wouldn't interfere, but the pain meds seemed to take twice as long to kick in! So I stopped it until my pain was manageable without pain medication.

BTW, does anyone know if it is OK to take 5htp while on LDN?

 

[mobetterblues]

BTW, does anyone know if it is OK to take 5htp while on LDN?

i take 5htp at night - yes, it's safe and it all helps with sleep - i take Thorn 100mg with b6 in it - sometimes i feel like 100mg is too much so i split it in half - i also use semorelin for sleep - wow, it works so very well because it acts on the messengers for pituitary - the first time i injected it, i woke up the next day and said 'well, that's what it's like to sleep!!!!'

 

[belize44]

i take 5htp at night - yes, it's safe and it all helps with sleep - i take Thorn 100mg with b6 in it - sometimes i feel like 100mg is too much so i split it in half - i also use semorelin for sleep - wow, it works so very well because it acts on the messengers for pituitary - the first time i injected it, i woke up the next day and said 'well, that's what it's like to sleep!!!!'

That's good to know. Thanks!

 

[belize44]

Well, I had to stop the LDN entirely. First of all, I strained my Gracilis muscle, and was in excruciating pain. I was able to benefit from painkiller because of the extremely low dose of LDN I was on. As a rule, I try not to take painkillers more than two days in a row, because they disrupt so much else for me; downed mood, digestion issues, etc. But when I resumed the LDN at a slightly higher dose I began to see an increase in my diastolic pressure. So I've stopped it entirely.

On top of that, I have my yearly oral Herpes outbreak and this is the worst one yet! for a week I have felt crushingly ill, and for once my below temperature was actually normal for awhile. My doc prescribed the usual antiviral medicine, and for the first time I have had adverse affects from it. So after only one day on it, I have had to stop it. Here I sit with an excruciating sore on my bottom lip and no relief in sight. I know that it will pass eventually but I always was able to take antivirals with no problem whatsoever.

Does anyone know of a natural remedy for cold sores?

 

[Firefly_]

I believe lysine is useful for that.

 

[belize44]

I believe lysine is useful for that.

Thanks! I found that I had some Lysine that's about two years old, but I am taking it anyway until I can get some new stuff.

 

[Firefly_]

Cool, hope it helps quickly.

 

[PatJ]

Does anyone know of a natural remedy for cold sores?

Here is a list of 16 natural treatment and prevention measures, with more suggestions in the comments section.

 

[belize44]

I am now up to the number 7 on the little syringe thingy. This is titrated in distilled water from a 1.5 capsule. I had a week of uncontrolled weeping, but that seems to have passed. I am sleeping better, too.

 

[serusaert]

i have completed day 4 of LDN - 1.5 mg taken @ bedtime

possible events related to LDN:

1. small degree of insomnia
2. feel more mellow and generally have less mental activity of the defensive sort - i think this is the reduced hypervigilance that some report (yes, i do have PTSD)
3. less neuropathy in feet - the tingling is more mild.
4. slight headache that went away after two hours
5. muscle spasm in chest and back - this actually hurts - and i hope it goes away soon
6. increase in anxiety for an hour or two after taking the LDN

possible confounding issues:

1. i take ibudilast 10mg 3 X day
2. i smoke cannabis - usually just 1-2 puffs of sativa at night
3. i take gabapentin 300 mg, melatonin, and 5-htp at bedtime
4. i am taking the arginine/citrulline supplement
5. i am recovering from PEM induced by a sinus surgery 2 weeks ago
6. i do the ketogenic diet and have been in nutritional ketosis for 4 months

getting a script for naltrexone is not easy. my gp has flatly refused to either give me an RX for full strength naltrexone (that i can dilute) or to fill out an online script form that i can use with a compounding pharmacy.

i'm currently getting LDN mailed from israel (buyldn.com) but will likely either:

1. buy full strength naltrexone from an online india pharmacy and make my own dilution
2. see a naturopath and get a legit RX that i can fill in the US/Canada

 

[belize44]

getting a script for naltrexone is not easy. my gp has flatly refused to either give me an RX for full strength naltrexone (that i can dilute) or to fill out an online script form that i can use with a compounding pharmacy.

This. I am not taking LDN anymore because my Rheumy refused to write a script for the full strength so I could save money; my insurance would have covered the 50 mg but I must pay out of pocket for the compounded LDN. So for now, I no longer take it because I can't afford it. Also, while it did much of what you described above, I found that it did nothing for the more severe pain that I suffer from. I am currently seeing a pain management specialist and will probably be getting shots for the more troublesome areas.

 

[*GG*]

This. I am not taking LDN anymore because my Rheumy refused to write a script for the full strength so I could save money; my insurance would have covered the 50 mg but I must pay out of pocket for the compounded LDN. So for now, I no longer take it because I can't afford it. Also, while it did much of what you described above, I found that it did nothing for the more severe pain that I suffer from. I am currently seeing a pain management specialist and will probably be getting shots for the more troublesome areas.

Perhaps you could have your Dr write the script a little different? Maybe say you take 3 a day, but do Not, so a 1 month supply will last 3 months. I have been off of LDN for some time now as well, over 3 years awaiting disability, so very low on cash!

But I have been trying to figure this out. I called my usual filler of the compounded LDN, and they said they would charge me about $70. If I had income, this would seem feasible, but not at this time

GG

 

[keenly]

Well, I had to stop the LDN entirely. First of all, I strained my Gracilis muscle, and was in excruciating pain. I was able to benefit from painkiller because of the extremely low dose of LDN I was on. As a rule, I try not to take painkillers more than two days in a row, because they disrupt so much else for me; downed mood, digestion issues, etc. But when I resumed the LDN at a slightly higher dose I began to see an increase in my diastolic pressure. So I've stopped it entirely.

On top of that, I have my yearly oral Herpes outbreak and this is the worst one yet! for a week I have felt crushingly ill, and for once my below temperature was actually normal for awhile. My doc prescribed the usual antiviral medicine, and for the first time I have had adverse affects from it. So after only one day on it, I have had to stop it. Here I sit with an excruciating sore on my bottom lip and no relief in sight. I know that it will pass eventually but I always was able to take antivirals with no problem whatsoever.

Does anyone know of a natural remedy for cold sores?

Monolaurin aka lauricidin.

Brilliant natural anti viral from coconuts, I also agree with lysine.

Sorry to hear LDN was not great for you. I was looking into this recently. I have never tried any meds, but have been so bad this month I have thought about it. Looking to try cell signaling factors, but need help from somebody in U.S.

The search goes on.............

 

[Diwi9]

I'm new to LDN too and am feeling off today. Dry skin, sickish, spacey, and GI upset. I titrated up last night, but did not make the connection until I saw this thread. Thank you!

 

[serusaert]

i bumped up to 3.0 mg two nights ago. i had a headache for a day and then it resolved. i had the same headache when i started 1.5 mg. that's pretty consistent.

i definitely feel the effect - i feel very mellow, especially in the am. this stuff really calms my shit down. but then again, i do have PTSD and i wonder if it works more on those of us who have these issues.

re sourcing, i finally got a doc within my HMO to write a script for Naltrexone. my GP wanted nothing to do with it. but i now have access to what amounts to a decade of LDN supply - 12 bottles of 30 pills of 50 mg strength. just one bottle, when diluted, is 333 doses. here is a link to a page that shows some info on diluting: http://davidnixon.over-blog.com/measuring-low-dose-naltrexone-from-a-50mg-tab

interestingly, the actual product that my HMO sources is the same Sun pharma Revia from India that we can buy online without RX. btw, i got the fact sheet and the filler in this is lactose.

 

[hinterland]

Interesting. I noticed increased dryness of nasal airway during and after taking LDN, and possibly increased susceptibility to respiratory symptoms while taking it, by which I mean a respiratory infection I had wouldn't clear up until after stopping it. Otherwise it had some good effects, at least initially: improved cognitive function and energy levels for the first 3 or 4 weeks.

I too experience dry skin, hair, nasal mucosa, eyes; and it occurs as a sensitivity reaction to many nutritional supplements that I try. It's weird. It started to happen after taking mega dose B5.

I am worried about some side effects however, I was taking it with the hope of it also helping the sjogrens-type symptoms that I've been experiencing, only I've noticed they've actually gotten slightly worse.

It is the only side effect I've experienced at all, and I find that puzzling because since I've been on the LDN my muscle and joint pain has reduced considerably.

Has anyone else heard of LDN increasing incidence of dry mouth, eyes, and GI tract, etc?

If so, is there anything I can do to offset that?