Discussion in 'General ME/CFS News' started by Daisymay, Oct 3, 2014.
The above is a abstract being presented at the International Cytokine and Interferon Society to be held in Melbourne in October:
Perhaps the interesting bit is
The CFS patients were diagnosed using ICC. The sample sizes are small.
I've no idea what different cytokines do!
Thanks for pointing out this abstract.
I would be very interested in reading the full article.
I suspect there is no full article, since this is due to be published in a volume dedicated to conference abstracts. That usually means that this is a preliminary communication in abstract form only.
There is a rather embarrassing technical problem in the abstract in that some p values are given as 0.000! Probabilities are never zero in this context. I wonder if the senior authors checked the abstract! I think there may also be a Bonferoni correction problem. It looks as if the authors did at least 28 calculations that address the question of whether CFS has a specific cytokine profile in comparison to normal and MS. That means that we may have to think about multiplying all the p values by something like 28 (a Bonferoni correction). It is not as simple as that but I would wait to see a full peer reviewed report before passing judgment on these findings.
Thank you for highlighting these concerns.
I agree that it is wise to exercise caution before passing judgment on these (or any) findings.
Mady Hornig has said that pwME have high levels of interferon-gamma (IFN-γ) in the first 3 years only. I wonder how long the subjects in this study had been ill.
Interferons can cause low mood among other things.
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