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Cytokine profiles of chronic fatigue syndrome and multiple sclerosis patients

Discussion in 'General ME/CFS News' started by Daisymay, Oct 3, 2014.

  1. Daisymay

    Daisymay Senior Member

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    http://www.sciencedirect.com/science/article/pii/S1043466614004165


     
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  2. Daisymay

    Daisymay Senior Member

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    The above is a abstract being presented at the International Cytokine and Interferon Society to be held in Melbourne in October:

    http://www.cytokines2014.com/
     
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  3. user9876

    user9876 Senior Member

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    Perhaps the interesting bit is

    The CFS patients were diagnosed using ICC. The sample sizes are small.

    I've no idea what different cytokines do!
     
  4. Denise

    Denise Senior Member

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    NK17 likes this.
  5. Jonathan Edwards

    Jonathan Edwards "Gibberish"

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    I suspect there is no full article, since this is due to be published in a volume dedicated to conference abstracts. That usually means that this is a preliminary communication in abstract form only.

    There is a rather embarrassing technical problem in the abstract in that some p values are given as 0.000! Probabilities are never zero in this context. I wonder if the senior authors checked the abstract! I think there may also be a Bonferoni correction problem. It looks as if the authors did at least 28 calculations that address the question of whether CFS has a specific cytokine profile in comparison to normal and MS. That means that we may have to think about multiplying all the p values by something like 28 (a Bonferoni correction). It is not as simple as that but I would wait to see a full peer reviewed report before passing judgment on these findings.
     
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  6. Denise

    Denise Senior Member

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    Thank you for highlighting these concerns.
    I agree that it is wise to exercise caution before passing judgment on these (or any) findings.
     
  7. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    Mady Hornig has said that pwME have high levels of interferon-gamma (IFN-γ) in the first 3 years only. I wonder how long the subjects in this study had been ill.

    Interferons can cause low mood among other things.
     

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