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+/+ Cytochrome P450 enzymes (liver detox phase 1)

Discussion in 'Alternative Therapies' started by jason30, Aug 9, 2017.

  1. jason30

    jason30 Senior Member

    The Netherlands
    Hi all,

    The MTHFRSupport Variant Report v2.5 based on 23andme says that I am homozygous ( +/+ ) for these Cytochrome enzymes:
    • CYP1A2*1F
    • CYP1B1 L432V
    • CYP1B1 N453S
    • CYP1B1 T241A
    • CYP2B6 T23499C
    • CYP2C19 T98C
    • CYP2D6 C186G
    • CYP2D6 T130G
    • CYP2D6*2 S486T
    • CYP3A4*16 T185S
    I am new to these enzymes as well as genetic mutations.
    What's the next step? I wonder if this needs some action and where I can find more information about it.

    Thanks in advance for any help/tips.
  2. alicec

    alicec Senior Member

    MTHFRsupport seems to like quantity not quality; it identifies as many variants as possible but most of them do nothing or have unknown significance.

    Just because a variant is identified doesn't mean there are any consequences.

    There are many CYP enzymes with varying roles in phase I detox and other activities such as synthesis and catabolism of steroids. They are divided into families and subfamilies with about a dozen members of families 1,2,and 3 being responsible for drug metabolism.

    The genetics of CYPs are complicated and it is often combinations of SNPs, or deletions and duplications that determine things like overall drug metabolism.

    Many of the sites which analyse 23 and me results are not very helpful in predicting your drug metabolism status.

    Promethease doesn't do a bad job so if you have 23 and me data you could try running it through that site. It would be an inexpensive way of maybe getting an idea if you have serious CYP problems.

    23 and me, however, doesn't test all relevant SNPs so specialised testing would be necessary to really predict drug response. This could be something to consider if you are concerned about adverse drug reactions.

    Here is a review of CYPs and drug metabolism. It is fairly heavy going but you can just look at the figures and tables which give valuable information on which CYPs do what and what is known about the genetic variants. You can see if any of the variants identified by MTHFRsupport are listed.

    Fig 1 is a pie chart showing the breakup of drug metabolism among the various CYPs.
  3. jason30

    jason30 Senior Member

    The Netherlands
    Thanks a lot Alicec!

    It's very complicated indeed and difficult to say if it's really responsible for some reactions.

    I will run the test through Promethease to check if there are some CYP problems.
    The main reason I am interested in it is that I have some liver issues (MCS and mold illness). There is an imbalance of phase 1 and 2 and I wonder if I can do something myself to have a better performing phase 1.

    But my first reaction is to leave it as it is, because of the difficulty.

    Thanks again!

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