Hi all, I've been working on getting my auxiliary support supplement stack ready before starting methylation treatment (electrolytes, L-histidine which has helped cognitively since I'm low histamine, ACES multi without b12/folate and the necessary minerals) My 23andme tested +/+ for MTRR and COMT, but -/- for MTR Im guessing that I need b12, but not methyl b12. Every time I've tried very small doses of mb12 (100mcg) its ended in spiraling depression and rage, same goes for methylfolate and hydroxy b12, but cyanocobalamin hasnt affected me in the past from what I recall. I feel like the mb12 and methylfolate place a burden on my COMT and their unmethylated counterparts like cyano b12 and folinic might be better for me. I fit the classic overmethylated bio type to a T as well. Am I doing the right thing or might this end badly for me? Can someone lead me in the right direction?