My situation is this, copper supplementation stops panic attacks and severe anxiety for me in low doses(150mcg). And every time I take a supplement that antagonizes copper (zinc, manganese, vitamin C, potassium, B vitamins) I end up with this severe anxiety and feel not right in the head, and that will only cease with copper supplementation. I've also noticed sometimes, clearing of cog fog, increased verbal fluency and some energy increase when taking copper. But then with continued supplementation it causes problems of its own. I get a depressed/low mood feeling, and then I start thinking "am I crazy, taking copper supplements? Maybe I am poisoning myself with this heavy metal" And then I stop it immediately, and then the cycle begins over again. The thing is I never take more than the RDA in supplementation. For example after a break from supplements, I took 150mcg(15% of 100% RDA capsule) which is my typical anxiety/panic stopping dose, then the next day I took 800mcg which is less than half the RDA, but I still got a depressed feeling. My question is, could this negative feeling could be die off? Maybe the copper is killing some pathogens and causing a herxheimer? Which would mean its a good thing and I should continue with it. The other theory I read is for "biounavailable copper", meaning I can be toxic and deficient at the same time. The proponents of that theory suggest taking zinc to force the biounavailable copper out of the body, but i'm not really sold on this theory. My own personal experience is I one time megadosed vitamin C for 3 weeks and after that I had terrible anxiety and dizziness that persisted for 2 weeks and that immediately stopped with copper supplementation. Is it a straight copper deficiency? metallothionein deficiency or dysfunction? Both my serum copper level and ceruloplasmin came back smack bang in the middle of the range(but I have read these are both poor indicators of copper status). I have a hair analysis that shows high copper(again, I have read hair analysis is not reliable). Anyone else supplement with copper? Whats your experience?