Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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COMT mutations and mercury effects in children

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Helen, Apr 21, 2014.

  1. Helen

    Helen Senior Member

    Thanks to Drs. Nancy Mullen and Amy Yasko for highlighting this study.

    J Toxicol Environ Health A. 2014;77(6):293-312. doi: 10.1080/15287394.2014.867210.
    Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children.
    Woods JS1, Heyer NJ, Russo JE, Martin MD, Pillai PB, Bammler TK, Farin FM.
    Author information

    Mercury (Hg) is neurotoxic and children may be particularly susceptible to this effect. A current major challenge is identification of children who may be uniquely susceptible to Hg toxicity because of genetic disposition. This study examined the hypothesis that genetic variants of catechol-O-methyltransferase (COMT) that are reported to alter neurobehavioral functions that are also affected by Hg in adults might modify the adverse neurobehavioral effects of Hg exposure in children. Five hundred and seven children, 8-12 yr of age at baseline, participated in a clinical trial to evaluate the neurobehavioral effects of Hg from dental amalgam tooth fillings. Subjects were evaluated at baseline and at seven subsequent annual intervals for neurobehavioral performance and urinary Hg levels. Following the clinical trial, genotyping assays were performed for single-nucleotide polymorphisms (SNPs) of COMT rs4680, rs4633, rs4818, and rs6269 on biological samples provided by 330 of the trial participants. Regression-modeling strategies were employed to evaluate associations between allelic status, Hg exposure, and neurobehavioral test outcomes. Similar analysis was performed using haplotypes of COMT SNPs. Among girls, few interactions for Hg exposure and COMT variants were found. In contrast, among boys, numerous gene-Hg interactions were observed between individual COMT SNPs, as well as with a common COMT haplotype affecting multiple domains of neurobehavioral function. These findings suggest increased susceptibility to the adverse neurobehavioral effects of Hg among children with common genetic variants of COMT, and may have important implications for strategies aimed at protecting children from the potential health risks associated with Hg exposure.

    PMID: 24593143
    [PubMed - in process]
    PMCID: PMC3967503

    Full article:
    NK17 likes this.
  2. A.B.

    A.B. Senior Member

    It's hard to understand how anyone could think that putting the metal responsible for the saying "mad as a hatter" into human mouths would be a good idea.
    NK17, PeterPositive and tdog333 like this.
  3. Valentijn

    Valentijn Senior Member

    I'd be very wary of a study which only finds results in sub-groups, especially when so many variables are being studied at the same the time.
    barbc56 likes this.

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