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COMT MB12 rage

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Gondwanaland, Mar 23, 2015.

  1. Gondwanaland

    Gondwanaland Senior Member

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    What is the antidote when someone 2x +/+COMT had too much MB12?
     
  2. Sherpa

    Sherpa Ex-workaholic adrenaline junkie

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    Niacin? I don't have COMT but it helped when I was having MAO A issues
     
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  3. Gondwanaland

    Gondwanaland Senior Member

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    How could I forget THAT?

    [​IMG]

    My husband is taking B2 to try to quit the SSRI, but had back pain, and I used 1,200 mcg of B12 drops to massage his back. A couple of hours later he called me saying he wanted to kill everyone who crossed his path :eek:

    Thanks, Sherpa!
     
  4. Gondwanaland

    Gondwanaland Senior Member

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    hmmm he will kill ME if I cause him to flush :rolleyes:
     
  5. Gondwanaland

    Gondwanaland Senior Member

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    There he is, with a red face and not any calmer after 25mg niacin... I wonder if he would do better with niacinamide... I don't want to give him uric acid problems...
     
  6. PeterPositive

    PeterPositive Senior Member

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    Niacinamide does the trick for me. Niacin is not my friend either :)
    I typically take 100mg.
     
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  7. adreno

    adreno PR activist

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    Nicotinamide will work fine.
     
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  8. Gondwanaland

    Gondwanaland Senior Member

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    Please help me...
    One would think that after >1 year reading about vitamins I would know what to do...
    I took him to my dr to get her help about what to give him, but she prescribed him her standard protocol that apparently "works for everyone" to raise serotonin and dopamine :rolleyes:
    I just didn' realize it when there was methionine in the prescription alongside with B2...
    He will actually do very well with the serotonin rasing stuff (unlike myself), but he must avoid the dopamine ones :ill:
     
  9. Gondwanaland

    Gondwanaland Senior Member

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    Thank you digi for posting this video
    So the inflammation (pain) that my husband has is from too much dopamine! Is that the same mechanism through which B6 causes neuropathy?
     
  10. Gondwanaland

    Gondwanaland Senior Member

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  11. Gondwanaland

    Gondwanaland Senior Member

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    My husband is taking:

    1/2 at breakfast, 1/2 at lunch:
    5-Htp 25mg
    L-Arginina 30mg
    L-Taurina 30mg
    CoQ10 30mg
    Aspartato Mg 30mg
    Potássio chelate 30mg
    Inositol 50mg
    W3 50mg
    Vit B2 10mg
    Quercitina 30mg
    Manganês chelate 500mcg
    G biloba 20% 30mg
    Vanádio chelate 100mcg
    Zinco chelate 10mg
    Curcuma longa 75mg
    Piperina 10mg
    Metionina 30mg
    Pycnogenol 50mg
    Licopeno 4mg
    Crisina 50mg

    at 6PM:
    5-Htp 25mg
    Vit B6 15mg
    Mg Glycina 30mg
    Quercetina 20mg
    Rutina 50mg
    Curcuma longa 80mg
    L-glutamina 50mg
    FOS 50mg
    Silimarina 50mg
    Vanádio chelate 100mcg

    He is having back pain probably from excess catecholamines
    Green urine from vanadium
    The dr added vanadium and manganese b/c he has high insulin
    I have MB12 drops at home so she hasn't added it to the formula
    I also give him Gamma E + fish oil
    Silymarin has been causing us to sleep with curled wrists
    His homocysteine is highish (>9), while B12 levels are >700

    I am thinking to cut some stuff off of his formulae
    Suggestions?
     
  12. Crux

    Crux Senior Member

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    Well, this is the most difficult thing.
    I want to help because you are so helpful to others, and, you are a most likable person!

    My Spanish is weak,And what is W3?

    Where is your husband's back pain located, specifically? Is it near organs or posterior liver?

    Curcumin has methyl groups, but I don't think the dosage is high. ( I have gotten insomnia from it, but 'everything' messes with my sleep.)

    Men might not need a lot of vitamin E.

    I've had some kind of manic-y times with fish oil and cod liver oil.

    When I took milk thistle for a long period, I began to have pain, acidic type. (?)

    There,Have I made a mess of things?:redface:
     
  13. Gondwanaland

    Gondwanaland Senior Member

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    Thanks!!! You just made my day :redface::D
    My Spanish is also weak, I speak Portuguese ;) W3= omega 3
    Nope, not that pain (I have that). he has muschle rigidity which is helped by Xdermal MB12, but not at the same time as this supps :eek:
    I didn't know that! His sleep is totally messed up and seems to get worse with this supps - no wonder o_O
    I think he does, b/c his HDL is very low. Vit E has been keeping my HDL >100 :jaw-drop: I am taking a break from it
    COMT manic-y? Excess dopamine?
    Acidic stomach?
     
  14. Crux

    Crux Senior Member

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    :hug:

    My Spanish is also weak, I speak Portuguese ;) W3= omega 3[/QUOTE]

    oops,:redface:, about the language! W3 s also make me kind of manic, with insomnia.

    This is a blooper on my part, inserting my own symptoms. Do y'all ever use DMSO for muscle pain?

    [QUOTEI didn't know that! His sleep is totally messed up and seems to get worse with this supps - no wonder o_O[/QUOTE]

    Some people have reported insomnia from taking turmeric later in the day, so maybe curcumin earlier?

    [QUOTEI think he does, b/c his HDL is very low. Vit E has been keeping my HDL >100 :jaw-drop: I am taking a break from it[/QUOTE]

    Interesting, I thought it was saturated fat that increased HDL. Must be a variety of things...exercise?



    [QUOTECOMT manic-y? Excess dopamine?[/QUOTE]

    I don't have the 'ususal' COMTs, must be some other cause. I understand COMT++ can be a handful, though.


    [QUOTEAcidic stomach?[/QUOTE]

    It could have been back then, I was taking a lot of HCL, HC, fermented foods, and probiotics. I think there's another potential irritant in milk thistle/ silymarin. I'll look it up.


    Sorry about this sloppy post; I still don't know how to do quotes.:redface:
     
    Last edited: Mar 25, 2015
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  15. picante

    picante Senior Member

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    I hope the flush disappeared quickly! Sorry I wasn't on here yesterday, dear izzy!

    As you know, my husband has double COMT +/+ and MAO A +. Niacin works fine when he has too many methyl groups, but **so does hydroxycobalamin**. He does really well on HyB12 with a teeny bit of MeB12. He also has no problems with AdB12.

    Too much MeB12 makes him dopamine deficient over time. That's his bump-on-a-log state. He doesn't get rage; he becomes inert.

    This is what stands out to me on your long list:
    Aspartato Mg 30mg

    Aspartic acid (aspartate) is excitotoxic. It is an excitatory neurotransmitter, and according to Dr. Blaylock, can lead to neurological diseases.
     
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  16. picante

    picante Senior Member

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    And this is a precursor for glutamate, another excitotoxin. Glutamate and aspartate are both necessary neurotransmitters, but in excess they are dangerous. Do you know anything about his glutamate-to-GABA conversion? I know mine doesn't work all that well. Is he sensitive to MSG or any of the "flavorings" and additives that contain glutamate?

    http://articles.mercola.com/sites/articles/archive/2004/05/01/glutamine.aspx

    Edited: Do you know whether this supp is reduced L-glutamine or oxidized L-glutamine?
     
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  17. Gondwanaland

    Gondwanaland Senior Member

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    Any idea why?
    Definetly! :thumbsup:
    Anti-oxidants keep cholesterol from oxidizing :smug:
    It must be salycilates, sulphur and histamines o_O
    It's a no-brainer: select, click reply and write below it. For advanced users just add to multiquote and later insert the replies below each quote ;)
     
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  18. Gondwanaland

    Gondwanaland Senior Member

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    It did, and it seemed to have helped
    Both he and I get sleepy from it
    We never tried AdB12
    Deficient??? I thought the rage was from too much dopamine. Does +/+COMT breaks dopamine down quickly or slowly? I only know about MAO-A being slow to break down serotonin. I have read the SNP interpreting guide at least 100 times and never know it :bang-head:
    I am aware of that, but I thought that low doses would help with energy
    What symptoms should I look for?
    Always loved chinese food, but we haven't eaten that suff in ages
    The more ordinary one (that I don't know which is, probably oxidized, right?)
     
  19. Crux

    Crux Senior Member

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    All I've found about omega 3 is that it is a brain stimulant. I agree.

    Silymarin and milk thistle are high in oxalates. They bother some folks, but I don't think I'm one... hope not, diet is too restricted now.

    Sometimes, 'no brainer' :confused: describes me well, but not in the way that you've defined it.:lol:

    Are things better for your husband today? Hope so.
     
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  20. picante

    picante Senior Member

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    I'm on shaky ground here, because I don't know the symptoms of dopamine excess, other than anxiety.

    However, the COMT enzyme breaks down dopamine, so +/+ people have trouble breaking down dopamine, which builds up until ... the feedback mechanism kicks in, and they start making less of it! That's why they wind up deficient, with depression & lack of motivation being major.

    Dopamine breakdown uses up methyl groups. When the COMT enzyme is not functioning well, methyl groups can accumulate to excess, especially when the person is taking MeB12 and Mefolate.

    For my DH, an increase in MeB12/Mefolate led to massive depression & inertia back in November, and when I figured out what was going on, we dosed him up on niacin. Three large doses and he was drastically better by bedtime. And totally fine the next day for work!

    Your DH's rage episode reminds me more of my own experience with trying to raise MeB12/Mefolate and trying to add in B-minus (Lynch's B complex). Apparently, either of those depletes my thiamine severely. You led me to this conclusion with your links to other threads about B vitamins, dear Izzy!

    I'm now a total fan of thiamine, because it gets rid of the symptom cluster I was having: anger, dwelling on people who've treated me poorly, insomnia, hot flashes, and pain at the base of my skull above my axis. I'm taking thiamine mononitrate and Benfotiamine, both! My body has a big need for them right now.

    I am convinced that the B2 or B3 in the B complex were depleting my thiamine, and even though there's a little thiamine in the formula, it wasn't anywhere near enough!
     

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