Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
Discuss the article on the Forums.

compare and contrast - calling the experts

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by golden, Feb 18, 2013.

  1. golden

    golden Senior Member

    i was hoping to understand better dr.myhills protocol and the methylation protocol by rich.

    for example both protocols measure glutathione - however have different ranges.

    could the experts tell me where the similarities and more importantly to me, where the contrasts lie.

    i gather that rich felt that the methylation protocol was the underlying cause of the mitochondrial dysfunction.

    i think the pros and cons of each protocol would help one immeasurably when trying to make an informed decision and informed consent upon experimenting with these protocols on oneself.

  2. golden

    golden Senior Member

    Also i have had to stop several supplements due to bad reactions.

    Is there a preferable order.

    For example to me, it seems like beginning just with Glutathione for a couple of weeks first would be sensible.

    Then adding other supplements which may cause an off load of toxins...

    The co- q10 gets my heart racing way out of control- not happy with that.
    The magnesium brings on severe fatigue.
    The d3 has a horrible effect i cant describe...

    Is there a better order to take these supplements?


    I am very very pleased with turmeric powder - i feel it to be highly nourishing.
  3. Sushi

    Sushi Moderation Resource Albuquerque


    Rich valued the test of reduced glutathione (Health Diagnostics) rather than total glutathione. I don't know which value Dr. Myhill is using. Health Diagnostics tests both reduced glutathione (this is what the body uses) and oxidized (not what you want.)

    There is a lot of discussion about supplementing glutathione -- with some strongly for and some strongly against. It is not uncommon to have a difficult reaction to it.

    I'd guess some good testing might be helpful for you to see what is going on with your response to supplements.

    Best wishes,
  4. golden

    golden Senior Member



    Red cell
    Glutathione peroxidase (GSH-PX) 67-90 (U/gHb)

    red cell
    Glutathione (GSH) 1.7 - 2.6 mmol/l

    Methylation Protocol:

    Glutathione (oxidised) 0.16-0.50
    Glutathione (Reduced) 3.8 - 5.5 ( cant find measurement values)

    Here are the two protocols for Glutathione measurements. I am not sure what any of that means? If they are the same or different and if different measurements, why?

    I think Glutathione is the only similarity in blood tests. I dont think thete is any methylation panel tested on the Myhill test?

    Thanks Sushi. What tests would tell me why i am having supplement problems?
  5. invisiblejungle

    invisiblejungle Senior Member

    This is from Rich VanK's write-up about the methylation panel:

    "The level of GSH in the plasma is likely to be more reflective of tissue intracellular glutathione status than the more commonly and more easily measured red blood cell or (essentially equivalent) whole blood glutathione level, which is about three orders of magnitude greater, because red blood cells are normally net producers of glutathione. Also, knowledge of the level of the reduced form, as distinguished from total (reduced plus oxidized) glutathione, which is more commonly measured, is more diagnostic of the status of glutathione function."

    I did the Genova NutrEval, which included whole blood glutathione. My result was near the high end of the reference range, which made me wonder, "So maybe methylation isn't a problem for me." Then I got the results of the Vitamin Diagnostics methylation panel, which showed low reduced glutathione and high oxidized glutathione. If Myhill's test is for red blood cell glutathione, then I don't think it would be as valuable.

See more popular forum discussions.

Share This Page