I am not sure if I should really discuss this openly here or not, please feel free to advise not to or delete this post if it is inappropriate in terms of the trial being confidential. Sussex ME and CFS association are running a study at the Royal Sussex hospital and Sussex university looking at understanding the biological mechanisms of CFS and Fibromyalgia. I would like to get involved for the sake of helping this thing progress and hopefully help make a small discovery but I have a few doubts. The study involves assessing POTS symptoms using a tilt table, encouraging inflammation in the blood stream and monitoring with brain scans and blood tests. (I can attach the information sheet if it is appropriate and am not breaching any privacy laws - that I may be already with this post). My doubts are whether their resources are developed enough to make significant discoveries that have not been made anyway by labs such as OMF and Montoya in America. Then, whether the data could just be collected to disprove any biological basis for ME and further prove the psychological angle (I know I'm a sceptic but who isn't in this dire situation?!) And probably my biggest doubt is that they will use a Typhoid vaccination to stimulate inflammation in the blood stream before monitoring the reaction. I spend a great deal of my life working extremely hard to lower inflammation through diet and supps etc. do I really want to raise it albeit temporarily? further to that, I am warned constantly about vaccines so is it even a good idea to receive one?