Hello, I'm curious to hear your story if you've had a bad reaction to Choline, or if you know how it relates to methylation. On two separate occasions I experimented with CDP Choline and Acetyl L-carnitine (which I understand contributes to Choline somehow). After a couple days both of these supplements caused me serious anxiety and brain fog. So much so that I could barely function. I stopped them immediately. I found this very odd because most people have the exact opposite experience. Most people take Choline to help with cognition. I've read other stories similar to mine. We seem to be in the minority, but I've never found a reason why. Then I learned I am homozygous for both MTHFR C667T and CBS A360A. Reading the wikipedia article on Choline I discovered that it is as a methyl donor. Choline plays a role in the methylation cycle and interacts with both MTHF and SAMe. There is more at play here than I understand, but I’m willing to wager my Choline reactions have something to do with my MTHFR or CBS mutations. Does this sound plausible? Could bad choline reactions be due to unaddressed methylation problems? Anyone else had similar reactions? Can anybody with more biochemistry knowledge offer some input on this? Any info is much appreciated.