in this
review,
"Growing evidence indicates 3,5-diiodo-L-thyronine (T2) as a biologically active thyroid hormone derivative able to affect energy metabolism (Goglia,
2015 and references within). T2 increases resting metabolic rate, enhances lipid utilization as a fuel substrate, and prevents the occurrence of diet-induced obesity and associated diseases, including liver steatosis, hypertriglyceridemia, hypercholesterolemia (Lanni et al.,
2005; de Lange et al.,
2011), and insulin resistance (de Lange et al.,
2011; Moreno et al.,
2011).
In SKM, T2 ameliorates the tissue's response to insulin that is impaired by a high fat diet (Moreno et al.,
2011). Importantly, previous studies have shown that, contrary to T3, T2 does not induce thyrotoxicity or undesirable side effects at the cardiovascular level at the doses used (25 μg/100 g rat body weight, Lanni et al.,
2005; de Lange et al.,
2011)."