triffid113
Day of the Square Peg
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http://link.springer.com/article/10.1007/BF01531575#page-1
This study says severely autistic kids have elevated HVA unlike normal kids and that B6 normalizes this. I have elevated HVA and HIAI that indicate dopamine and serotonin abnormalities. I never considered if a B6 analogue would fix because I have never not taken B6...so how could I be deficient? Unfortunately some of us consume some nutrients faster than others so maybe...But diet often trumps genes and I have to say B6 is mainly from protein and I eat a low protein diet (lifelong) so maybe that's the real problem. idk. There are so many variables it's hard to ever really know anything.
http://www.thecrystaltarot.com/articles/nutrition-articles/autism-alternative
Taken together, the studies seem to establish that vitamin B6 can benefit as much as half of children and adults with autism, and that its efficacy and safety are improved when combined with magnesium. None of these studies reported any significant adverse effects, even though the vitamin B6 doses ranged as high as 1,000 mg per day. Rimland emphasized that thousands of autistic people have been taking large daily doses of vitamin B6 (as much as 1,000 mg) for decades without experiencing problems. One publication reported on seven cases of peripheral neuropathy from daily intakes of more than 2,000 mg vitamin B6. (37) These patients were not taking magnesium or other B vitamins, as usually recommended when taking large vitamin B6 doses; nor were they taking the active form–P5P–that has not been associated with toxicity. In a later study, doses of 30 mg/day of B6 as pyridoxine hydrochloride (equivalent to as much as 2,100 mg for a 70 kg adult) were administered with 10 mg/kg/day of magnesium lactate to 11 autistic children for eight weeks; behavior significantly improved and no adverse effects were evident. (38) The latest ARI parent ratings in 2002 (24) reported a B:W ratio for vitamin B6 used alone of 4.1:1, for magnesium alone 5.2:1, and for the combination of vitamin B6 plus magnesium, 11:1.
Cases of hereditary impairment of pyridoxine metabolism have been described, sometimes manifesting as seizure disorder and autism symptomatology. (39) Conversion of vitamin B6 to its active form P5P by the liver can be compromised in some autistic children. For these cases P5P supplementation may work more effectively, although hyperactivity is a possible adverse effect. (40) An intake threshold for achieving benefit may be approximately 200 mg vitamin B6 (as pyridoxine) and 100 mg magnesium per day for the 70 kg individual. (41) In any case, the cumulative results from the double-blind trials and numerous other studies and case history reports are consistent with impressive efficacy of the combination of vitamin B6 and magnesium for autism, superior to either nutrient alone. (38,42-44)
This study says severely autistic kids have elevated HVA unlike normal kids and that B6 normalizes this. I have elevated HVA and HIAI that indicate dopamine and serotonin abnormalities. I never considered if a B6 analogue would fix because I have never not taken B6...so how could I be deficient? Unfortunately some of us consume some nutrients faster than others so maybe...But diet often trumps genes and I have to say B6 is mainly from protein and I eat a low protein diet (lifelong) so maybe that's the real problem. idk. There are so many variables it's hard to ever really know anything.
http://www.thecrystaltarot.com/articles/nutrition-articles/autism-alternative
Taken together, the studies seem to establish that vitamin B6 can benefit as much as half of children and adults with autism, and that its efficacy and safety are improved when combined with magnesium. None of these studies reported any significant adverse effects, even though the vitamin B6 doses ranged as high as 1,000 mg per day. Rimland emphasized that thousands of autistic people have been taking large daily doses of vitamin B6 (as much as 1,000 mg) for decades without experiencing problems. One publication reported on seven cases of peripheral neuropathy from daily intakes of more than 2,000 mg vitamin B6. (37) These patients were not taking magnesium or other B vitamins, as usually recommended when taking large vitamin B6 doses; nor were they taking the active form–P5P–that has not been associated with toxicity. In a later study, doses of 30 mg/day of B6 as pyridoxine hydrochloride (equivalent to as much as 2,100 mg for a 70 kg adult) were administered with 10 mg/kg/day of magnesium lactate to 11 autistic children for eight weeks; behavior significantly improved and no adverse effects were evident. (38) The latest ARI parent ratings in 2002 (24) reported a B:W ratio for vitamin B6 used alone of 4.1:1, for magnesium alone 5.2:1, and for the combination of vitamin B6 plus magnesium, 11:1.
Cases of hereditary impairment of pyridoxine metabolism have been described, sometimes manifesting as seizure disorder and autism symptomatology. (39) Conversion of vitamin B6 to its active form P5P by the liver can be compromised in some autistic children. For these cases P5P supplementation may work more effectively, although hyperactivity is a possible adverse effect. (40) An intake threshold for achieving benefit may be approximately 200 mg vitamin B6 (as pyridoxine) and 100 mg magnesium per day for the 70 kg individual. (41) In any case, the cumulative results from the double-blind trials and numerous other studies and case history reports are consistent with impressive efficacy of the combination of vitamin B6 and magnesium for autism, superior to either nutrient alone. (38,42-44)