Hi everyone, A thread with the answers I'm looking for may be out there but I haven't had any luck. I've had on and off success with supporting methylation and related processes via sublingual methylcobalamin and methylfolate and the necessary cofactors but I continue to struggle. About 1/4 of the time I seem to get really lucky and have phenomenal days with the regimen but then fall back to extreme fatigue, brain fog, high heat panic in stressful situations (i.e., very flustered very easily), sore/weak muscles, anti-social, flat, etc. Here are the steps I've taken to combat these issues over the past year: -High-dose folate with potassium support per Freddd's instructions -General potassium support (mild but only interment success) -Trying un-methylated versions of b12 and folate in the forms of hydroxocobalamin and folinic acid -Controlling inflammation with Turmeric -Addressing related mutations first (CBS, etc.) -Very low and slow regimens -Clean diet, positive outlook, etc. (all the general well-being advice) It seems, of course, that the biggest contributors to these issues are methylb12 and folate. I'm currently starting an R-ALA protocol with low dose methylation support per Cutler's guidelines. I've had quite a strong reaction to the R-ALA while dosing every 3-4 hours so heavy metal toxicity may be the root cause. I'm excited if this is the case in that I'll finally have an answer to my never-ending problems! Thanks in advance. Also, @caledonia, you have been incredibly helpful and any help would be appreciated.