Hi all, I've searched on this site and on google but nothing much comes up about the use of cannabis and tobacco if you have MTHFR problems. I came across the following piece of research that shows glutathione depletion is one of the many ways tobacco smoke causes its many diseases: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111221/ This article relating to the use of cannabis states that intracellular glutathione is reduced by 81%: http://www.ncbi.nlm.nih.gov/pubmed/10340948 This all sounds fairly unappealing to someone using these substances. Does anyone have any idea in pragmatic terms how harmful these substances are while trying to recover from severe vitamin deficiencies with CFS, neurological/brain dysfunction, etc? I had given up tobacco for a couple of months, but started having one or two in the morning. I noticed a couple of times I experienced nausea after having one in the afternoon around 4pm so just have the morning one or two now as it doesn't seem to cause nausea. The nausea may have been something else though. I like them, obviously, but i'm looking for a good reason to give them away for good . I also use cannabis from time to time and i'm currently enjoying its effects of an evening. It helps with my sleep which has been a problem for a long time, plus I enjoy the escapism. I re-started it a month ago to help break a cycle of severe insomnia. I'm just starting to get my health back after starting my methylation protocol but have quite a way to go. My sleep has improved too but I still like to have this as a crutch, but i'd happily give it away if it's likely to cause me harm. I don't plan to use it much longer anyway but if I could use it medicinally at all while doing the methylation protocol i'd be interested to know.