Hi,
My mum has rheumatoid arthritis and I'm trying to help her get on the methylation protocol. She takes methotrexate with which they prescribe folic acid (not folate), in 5 mg daily doses as methotrexate can deplete folate. I have the MTHFR polymorphism (+/-) so I want to assume my mum has that too and get her to switch to folate. My question is whether you are pretty much able to substitute methylfolate / folinic acid for folic acid at a similar dosage level, eg 5mg? She spoke to her doctor about this who (surprise, surprise) didn't know anything about it, but did agree to getting her homocysteine level checked.
I don't know if there are any other alternatives to methotrexate that she could look into, since depleting folate doesn't sound like a good idea. Hope this question is ok since I know it doesn't specifically relate to CFS, but I thought this would be the best place to ask.
Hope someone can help, thank you.
My mum has rheumatoid arthritis and I'm trying to help her get on the methylation protocol. She takes methotrexate with which they prescribe folic acid (not folate), in 5 mg daily doses as methotrexate can deplete folate. I have the MTHFR polymorphism (+/-) so I want to assume my mum has that too and get her to switch to folate. My question is whether you are pretty much able to substitute methylfolate / folinic acid for folic acid at a similar dosage level, eg 5mg? She spoke to her doctor about this who (surprise, surprise) didn't know anything about it, but did agree to getting her homocysteine level checked.
I don't know if there are any other alternatives to methotrexate that she could look into, since depleting folate doesn't sound like a good idea. Hope this question is ok since I know it doesn't specifically relate to CFS, but I thought this would be the best place to ask.
Hope someone can help, thank you.