Here are my detox results:
CYP1A2 164A>C rs762551 AC +/-
CYP1B1 L432V rs1056836 CG +/-
CYP1B1 N453S rs1800440 CT +/-
CYP1B1 R48G rs10012 CG +/-
CYP2D6 S486T rs1135840 CG +/
CYP2D6 2850C>T rs16947 AG +/-
CYP2E1*1B 9896C>G rs2070676 CG +/-
CYP3A4*1B rs2740574 CT +/-
GSTP1 I105V rs1695 AG +/- -------------------------------------- is this the Gluatathoine SNP you were talking about
caledonia?
SOD2 A16V rs4880 GG +/+ my only homozygous mutation
NAT2 I114T rs1801280 CT +/-
NAT2 K268R rs1208 AG +/-
GSTT1 Present (it says this is impossible to determine from 23 and me results)
Also I heard that (800 mcg of Pure Non-racemic L-methylfolate | 1,000 mcg of Methylcobalamin and Adenosylcobalamin Vitamin B12 was helpful for people with MTHFR Snp problems) is that untrue?
Those look pretty much like mine. The CYP1B1s are associated with estrogen dominance. The CYP2D6s and the next few are associated with problems with various meds. An upregulated SNP can be as problematic as a downregulated one. For example, for benzodiazepams, I do better with a longer acting variety like clonazepam instead of a short acting one like xanax.
Yes the GSTP is a glutathione SNP.
On a test my doc had me take, the SOD2 was reversed. I come out +/+ on this detox test, and -/- on my docs test. Now I'm confused - do I have a SOD2 issue or not?
I do have testing to show that I have a lot of oxidative stress, so that would make me think that I am indeed +/+ for this SNP. Or the mercury I have obliterates that and is the sole cause of my oxidative stress.
The NATs are associated with lung cancer, so best to avoid certain toxins and eat your fruits and veggies.
I forgot to mention, that Ben Lynch has a new interpretation called Strategene for $45. He spent two years researching it and I would actually defer to that for the methylation portion.
https://seekinghealth.org/product/strategene/
He only includes significant SNPs and that does include MAO A. He also has one called MAO B.
The detox interpretation is still good as far as I know. It's based on the Detoxigenomics test.
Remember that SNPs are just potentials, and just because you have certain SNPs, it doesn't mean they're expressed. So you if you don't have issues, you don't need to supplement. You could have the worst SNPs in the world and be perfectly healthy if your environment was healthy. The environmental portion is called epigenetics, or the environment's effect on gene expression.
Also if you decide to supplement with folate and B12, the amounts you quoted are normal ending amounts. If you're sick enough to be on this forum, I would suggest not starting with that amount. Instead start with very tiny amounts such as under 50mcg and gradually work your way up as tolerated. Even 50mcg could be too much for some people.
Have some nicotinic acid form of niacin and potassium gluconate on hand before starting, in case you run into problems.
The reason is that when you take these B vitamins, you're manipulating your methylation cycle, which controls over 40 major reactions in the body.
I have more info in my Start Low and Go Slow document, and also Roadblocks to Successful Methylation.