I have just started taking Methotrexate for my eczema, I have just seen that there is some link to improving ME. So far I have taken one small dose and it has made me very tired, my energy levels have dipped a lot. Is there many studies to show it can help ME, because if the side effects continue and my energy levels don't pick up I am very unlikely to stay on this medication, unless it has a dramatic effect on my eczema