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Breaking News: PLOS One issues Expression of Concern for PACE trial paper

user9876

Senior Member
Messages
4,556
I don't think they would be surprised at all. They were flagged this was going to happen, over a very long time period.

I suspect they were surprised that action was taken. I expect they hired expensive lawyers to try and block any action. Generally they have had an easy time getting the medical establishment to make excuses and exceptions for them.
 

AndyPR

Senior Member
Messages
2,516
Location
Guiding the lifeboats to safer waters.
AfME have just posted this on their Facebook page.
Screen Shot 2017-05-03 at 13.01.21.png

I decided to take a screenshot just in case it should disappear....
 

AndyPR

Senior Member
Messages
2,516
Location
Guiding the lifeboats to safer waters.
Typical AFME softness.

An expression of concern is more than "a few readers having concerns and asking for data." It is an acknowledgement by journal that something isn't right.
To be fair to AfME, and I don't often say that, all they are doing is quoting PLOS ONE. Obviously they could have added their own comment, which would have made their own position clearer, but the quote itself is from http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177037
 

Esther12

Senior Member
Messages
13,774
Paul McCrone the lead author of this paper.

https://twitter.com/paul_mccrone?lang=en

Paul McCrone
@Paul_McCrone
Christian, health economist, socialist, Lincon City fan, lover of pies and VW Beetles, runner.

Maybe he should add hypocrite to that bio. Very christian and socialist of him to be responsible for dangerous and harmful treatments for the benefit of the insurance co's like UNUM.

I find people like this unbearable. Always worth trying to be restrained, but some of his tweets trigger an impulse to start swearing... AAaargHH!
 
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Chrisb

Senior Member
Messages
1,051
Don't understand that statement from AfME.

"Board of trustees met last week....... We will communicate the outcome of this as soon as it has been agreed by our Board".

Does this mean that there was no agreement of the board at the meeting, and that a further meeting has to be held?

Or does it mean that there was agreement, but that the final terms of the communication have to be signed off by each member before it can be released?

Or does it mean that the board of trustees is something different to "our Board"?

Perhaps when the white smoke emerges from the chimney the world will know that all is ready.
 

Binkie4

Senior Member
Messages
644
Can anyone remember the details of Afme's promise in March where they gave the date of the Trustees' meeting, 28th April, and according to my memory said their decision would be announced the following week?

I know it's only Wednesday. Just trying to deduce what "agreed by our Board" means. It didn't commit to this week. Maybe we will have time to get bored! And maybe that signifies something.
 

Keith Geraghty

Senior Member
Messages
491
..could I ask we refrane from personal attacks - on anyone's religion or other - lets stick to the facts of the trial and the facts of how the trial authors (mainly White, Sharpe and Chalder) behaved around defending their actions in trial management and not disclosing data.

I think personal attacks on other matters is unhelpful.
 
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TiredSam

The wise nematode hibernates
Messages
2,677
Location
Germany
..could I ask we refrane from personal attacks - on anyone's religion or other - lets stick to the facts of the trial and the facts of how the trial authors (mainly White, Sharpe and Chalder) behaved around defending their actions in trial management and not disclosing data.

I think personal attacks on other matters is unhelpful.
I quite agree.

Although I must say it's unfortunate that you posted it just before I was about to make a snarky and obnoxious post about this:

lover of pies

In deference to your post I shall now have to bite my tongue instead.
 

user9876

Senior Member
Messages
4,556
Paul McCrone the lead author of this paper.

https://twitter.com/paul_mccrone?lang=en

Paul McCrone

He is the chair of the independent steering group for one of Crawley's trials (Fitnet-nhs I think). But clearly not very independent since he is clearly a big believer in the approach. Also given his role in hiding data from patients, outcome switching and failing to correct errors in this paper I would have issues with his ability to properly judge the conduct of a trial.
 

Keith Geraghty

Senior Member
Messages
491
...there is a clear need for independence to be a factor in consideration of who sits on these steering committees and ethics boards - loading them with colleagues or friends just goes against the rationale for having them in the first instance.

he also switched between median wage cost and mean wage cost to calculate social costs in different papers. costing value of a health care intervention is not clear cut process, but when you can decide how much ATP will cost (when in fact pacing costs nothing, its just a patient resting) and when you can decide this is x amount of hours carers will be needed, and then you can make up a cost of what that costs - economic evaulations of cost effectiveness are as open to manipulation as the effectiveness measures of the treatment -
 
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Murph

:)
Messages
1,799
I wonder if we could get Davis to ask Watson to request the data. He's not exactly anti-science rabble...