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Brain's immune cells key to maintaining blood-brain barrier

Discussion in 'Other Health News and Research' started by natasa778, Jan 11, 2016.

  1. natasa778

    natasa778 Senior Member

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    http://medicalxpress.com/news/2016-01-brain-immune-cells-key-blood-brain.html#nRlv
     
  2. lansbergen

    lansbergen Senior Member

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    To me that means do not inactivate microglia
     
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  3. lnester7

    lnester7 Seven

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    USA
    Why is it getting so activated in CFS? Is it that there is not good barrier?
     
  4. lansbergen

    lansbergen Senior Member

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    I think the barrier is attacked by the infectious agent or the immune response to it.
     
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  5. halcyon

    halcyon Senior Member

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    CNS infection is my vote.
     
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  6. Hip

    Hip Senior Member

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    I think it is a bit more complicated that that.

    Microglia can activate into the neuro-destructive mode (= classical activation), which is the "kill" mode that destroys pathogens; or they can activate into the neuro-protective mode (= alternative activation), which is the mode that repairs tissue and heals the brain.

    I imagine that if the microglia are repairing the blood-brain barrier, it will be the neuro-protective mode that is required.

    Quite a few factors (including LPS and mold toxins) seem to switch microglia from the neuro-protective mode into the neuro-destructive mode. And I would guess that an ongoing CNS infection would promote the neuro-destructive mode.

    More info at the bottom of this post.
     
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  7. lansbergen

    lansbergen Senior Member

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    Pathogens in neurons must be destroyed. How would you do that without damaging the cells?
     
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  8. Hip

    Hip Senior Member

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    Yes, but only if there are indeed pathogens present in brain cells such as neurons or glia that need to be destroyed.

    But what if microglia were activated into the neuro-destructive mode not because of pathogens in brain cells, but because of factors such as mold toxins, which induce the neuro-destructive mode?

    Or what if there were only relatively few brain cells infected with pathogens (ME/CFS brain autopsies examining enterovirus infections in the brain have found only a scattering of infected cells), but the microglial response to that infection was far stronger than was necessary, perhaps again due to mold toxins entering the brain, or due to immune phenomena such as microglial priming, that inappropriately amplifies and exaggerates microglial responses?
     
  9. lansbergen

    lansbergen Senior Member

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    Or what if the brain is infected with a pathogen for wich is not tested?
     
  10. roller

    roller wiggle jiggle

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    destroy lps and exotoxins/endotoxins produced by bacteria - then less microglia activation.

    but... even then.. its not really clear, if this reduced response (due to waste reducation) wouldnt be benefical to the bacteria/pathogens itself.

    we cannot solve this. so, we have to attack the pathogen.
     

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