knackers323
Senior Member
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I think there are many causes of fatigue even within the one person, this is why i think sometimes something will work and the next day it doesnt
Its very debatable if neurological symptoms are occurring due to structures being broken or not. Many people report feeling 100% normal lasting from hours to days to weeks, so maybe in a percentage of cfsers these issues arent from something being broken in the brain, its possible that outside issues are causing the neurological issues.
One example of something that can cause the fatigue and neurological issues is the actual immune system even if an active infection is going on. eg Many people feel terrible from the flu not just because of the flu virus itself but from the cytokines being produced from the immune system trying to fight the infection. I think this is why some people can feel better on high dose prednisone or maybe one of the newer autoimmune/anti inflammatory drugs like the tnf blocker enbrel. But its only treating apart of whats causing the fatigue which is the immune system itself, now if someone has an active infection then using these drugs to turn down the effects of the immune system can allow infections to thrive as we now dont have our immune system fighting the infection.
Dammed if we do and dammed if we dont sometimes.
What is the theory behind the high dose prednisone working? I got a fair bit of relief from using this?
I have also been thinking lately about the idea that cfs could be an autoimmune problem, well have many people tried immunosuppressants and anti inflamitorys? What did they find?