Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Brain’s Dumped DNA May Lead to Stress, Depression

Discussion in 'Other Health News and Research' started by InitialConditions, Oct 7, 2018.

  1. InitialConditions

    InitialConditions

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    https://medium.com/scientific-american/brains-dumped-dna-may-lead-to-stress-depression-14b5de787228

    Reproducing here as this requires a sign in to view.

    New research suggests genetic material from the mitochondria can trigger an immune response throughout the body

    Humans and other mammals react to stressful situations through a series of well-orchestrated evolutionary adaptations. When faced with a predator looking for its next meal, or with worry of losing a job, our bodies release a cascade of stress hormones. Our heart rate spikes, breath quickens, muscles tense up and beads of sweat appear.

    This so-called “fight-or-flight” response served our ancestors well, but its continual activation in our modern-day lives comes with a cost. Scientists are starting to realize stress often exacerbates several diseases, including depression, diabetes, cardiovascular disease, HIV/AIDS and asthma. One theory is hoping to explain the link between stress and such widespread havoc by laying the blame on an unexpected source — the microscopic powerhouses inside each cell.
     
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  2. IThinkImTurningJapanese

    IThinkImTurningJapanese Jester in Training

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  3. ljimbo423

    ljimbo423 Senior Member

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    I now wonder if physical activity or psychological stress, at least in ME/CFS, causes increased mitochondrial damage and higher levels of mitochondrial DNA. Triggering the immune system, flu-like symptoms, fatigue and PEM?

    This paper seems to be focused on psychological stress causing damaged mitochondria and their DNA to leak causing immune system activation.

    I think there are many things though that can damage the mitochondria and cause their DNA to leak. Like oxidative stress and toxins, etc.

    This paper might explain why high dose BCAA's have completely stopped the flu-like flares I use to get, for over 2 1/2 months now. Even though I have been much, much more active.

    BCAA's feed the krebs cycle in the mitochondria after the pyruvate dehydrogenase enzyme(PDH). PDH is the enzyme Fluge and Mella found to be inhibited in ME/CFS.

    Slowing the krebs cycle and reducing the amount of energy (ATP) the mitochondria make. BCAA's bypass PDH, feeding the krebs cycle and therefore allowing more ATP(energy) to be made.

    Improving mitochondrial function,I think, might slow the death of mitochondria and lower the amount of mitochondrial DNA triggering the immune system. Possibly stopping my flu-like flares.

    Very interesting article. link
     
    Last edited: Oct 7, 2018
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  4. Mary

    Mary Moderator

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    In 2010 testing done at Acumen Labs by Sarah Myhill ("Cell-free DNA in blood plasma") showed quite elevated cell-free dna in blood plasma for me: the reference range was up to 9.5, and mine was 22.7 - "highly significant" (over the top of the highest range).

    The test says this:
     
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