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Biomarkers Predict Rituximab Response in RA

Discussion in 'Rituximab: News and Research' started by jaybee00, Dec 30, 2016.

  1. jaybee00

    jaybee00 Senior Member

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  2. John Mac

    John Mac Senior Member

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    Liverpool UK
  3. Research 1st

    Research 1st Severe ME, POTS & MCAS.

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    Hi.

    Don't know if this of any use?


    And...

    And...
    Thanks.
     
    Murph and eljefe19 like this.
  4. Jonathan Edwards

    Jonathan Edwards "Gibberish"

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    I had not seen it. I am not that impressed. Our own group showed that the presence of rheumatoid factor or anti-CCP antibodies or high Igs were a pretty reliable indication of response in RA. But then we expected that in advance since without these one would suspect that it was not really RA but some other ( maybe T cell mediated) disease. This group has added in IL-33. It would have been much more helpful if they simply indicated the predictive value of IL-33 alone since the others we knew about. High IL-33 is presumably part of the EFFECT of the autoantibodies in RA so there is no reason to think it would be relevant in a disease where autoantibodies had a completely different effect - like binding to neurotransmitter receptors as might be the case in ME.

    So there is no conclusion here that IL-33 would be likely to be a biomarker for response in ME I think.
     
    TrixieStix, aaron_c, BurnA and 3 others like this.
  5. Kenny Banya

    Kenny Banya Senior Member

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    Australia
    Sorry to go a little off tangent, but I was certain I had RA, but none of the RA specific blood tests or even the contrast MRI suggested RA.
    For the hell of it, I forced my rheumatologist to agree to give me methotrexate, because methotrexate has been shown to stall the progression of RA, if caught early. He was apprehensive, but agreed, stating that only one person in his entire career practice had responded to methotrexate, AFTER not responding to prednisone/solone/steroids.
    Luckily, my CFS specialist said absolutely not to use it & that my symptoms were from CFS and it is an autoimmune response causing pain in my fingers, wrist & elbow joints.
    That said, I wonder if methotrexate has ever been tried for CFS.
     

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