Hi About 8-9 months ago I started to develop food intolerances, which I later identified as mast cell problems. I havent been diagnosed yet. I also have POTS and other heart related problems, which come from use of neuroleptics. Ive read elsewhere on the internet, that mast cell activation disorder, can happen as a result of these drugs. So when I started getting POTS, I was put on a beta blocker, which didnt cause mast cell problems for a year. I was then switched to another beta blocker, and I guess I started having problems with food then. Im now reading that beta blockers are not advisable in MCAD, but can they cause it? Im hoping my doctor will let my try a calcium blocker instead. Maybe some of you have tried a beta blocker and can comment on this, since I really dont think I can do without my beta blockers. If more than 6 hours pass without some beta blocker I start getting agitated and then the fast heart beat starts happening especially when I stand up. Then Im getting really anxious, almost panicking, until my beta blocker slows it down. But the beta blockers also give me brain fog, which might be because of mast cell degranulation. What do you guys think?