Until this morning I didn't even know what Mast cell Activation is. I've always sort of suspected I have CFS/ME, but doubted it too, because I can exercise. My story if you're curious and less brain fogged today. http://forums.phoenixrising.me/index.php?threads/my-story-i-can-exercise-so-what-is-it.48539/ Morning brain fog and stupor is one of my biggest problems. Last couple of days I've had something strange happen to me. I normally take my magnesium supplement at night. Last couple of mornings I took my magnesium just before I get up in the morning (say 5:30 am-ish when I ALWAYS wake up for no reason and stay awake for an hour), go back to sleep, and I wake up in the morning and feel like a million bucks. 3-4 hours later I'm at work, suddenly feel like someone is tugging at my nose, it dries up and inflames, my eyes get dry, I get dizzy and mental fogged. My IQ drops by a 100. Sort of how I feel in the mornings when I get up. I sit down, have a coffee and after lunch I feel better. The magnesium did something. If it's a cytokine activation related thing, what is the best magnesium form I take to maximize this effect? I take Magnesium L-Threonate for cognition, which is better for crossing blood brain barrier, and comes at lower doses. Which might be why it poops out by 11:30 am. Is there a better mag compound to stabilize mast cell/histamine reactions?