Hi, I am waiting for results from Amy Yasko re: genetic analysis, and will be having organic acids and amino acid urine analysis. I am also thinking of doing the methylation test that looks at current status. I have several indicators of poor methylation, including: Sensitivity to medications and supplements Particularly sensitive to any supplement linked to methylation, particularly if directly to glutathione Am becoming increasingly reactive to foods, whereas this didn't ever happen. This seems to especially be high histamine foods but also green veggies. Low scores on mitochondria tests Low glutathione, deficient B2, LOW coq10, low zinc and low magnesium. High homocysteine. Main stream doctors say nothing is the matter...... On Saturday I took about 3mg of B2 and felt better in mental wellbeing ways and in stamina than I had in ages, again on Sunday and yesterday. However, it didn't have the same effect today......and also each day I noticed more histamine reactions.I have really struggled to get to sleep for the past 3 nights.....is it all linked? I have never had sleep problems but wonder if anybody knows if insomnia is linked to methylation getting slower? Any suggestions gratefully received.