voner
Senior Member
- Messages
- 592
The pace of The publication of peer-reviewed papers on the Bacteria in the Gut & It's relation to the immune system is rather stunningly high right now. More and more I start to wonder what the involvement of bacteria is in all these seemingly confusing diseases in human population.
Here's one that popped up today, the articles behind a pay wall and Only the abstract is available for free....
Dig Dis. 2012;30 Suppl 1:74-7. doi: 10.1159/000341129. Epub 2012 Oct 11.
Toll-like receptors in gastrointestinal diseases.
author, Wagner H.
Source
Technical University Munich, Munich, Germany.
Abstract
Innate immune cells - and many other cells - express evolutionarily conserved, germline-encoded receptors that recognize seemingly pathogen-derived ligands (also termed pathogen-associated molecular patterns), thereby allowing the host to perceive infection. Although they were the first to be discovered, Toll-like receptors (TLRs) are not the only pattern recognition receptors. TLRs are unlikely to discriminate between commensals and pathogens in the gut microbiota. There is, however, increasing evidence that TLRs shape intestinal function. In addition, certain bacteria appear to drive either Th1/Th17 proinflammatory immune responses, or T regulatory responses. Furthermore, TLRs appear to trigger 'sterile' autoinflammatory responses by sensing metabolically altered host (self) components.
Copyright © 2012 S. Karger AG, Basel.
PMID: 23075872 [PubMed - in process]
Here's one that popped up today, the articles behind a pay wall and Only the abstract is available for free....
Dig Dis. 2012;30 Suppl 1:74-7. doi: 10.1159/000341129. Epub 2012 Oct 11.
Toll-like receptors in gastrointestinal diseases.
author, Wagner H.
Source
Technical University Munich, Munich, Germany.
Abstract
Innate immune cells - and many other cells - express evolutionarily conserved, germline-encoded receptors that recognize seemingly pathogen-derived ligands (also termed pathogen-associated molecular patterns), thereby allowing the host to perceive infection. Although they were the first to be discovered, Toll-like receptors (TLRs) are not the only pattern recognition receptors. TLRs are unlikely to discriminate between commensals and pathogens in the gut microbiota. There is, however, increasing evidence that TLRs shape intestinal function. In addition, certain bacteria appear to drive either Th1/Th17 proinflammatory immune responses, or T regulatory responses. Furthermore, TLRs appear to trigger 'sterile' autoinflammatory responses by sensing metabolically altered host (self) components.
Copyright © 2012 S. Karger AG, Basel.
PMID: 23075872 [PubMed - in process]
