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As far as your SNP specific treatments go. How are you deciding what to do about the SNPs? Medical practitioner? Based on Yasko's protocols? Or is there more readily available information out there about nutrigenomics that I'm ignorant of? I'm in the process of getting my testing done.
How much Solgar metafolin should he take per day considering below; he currently is taking 800mcg. x 2, but that was to offset a large amount of folic acid he no longer is taking. Should I just have him take one in the morning?:
2 multi's/day plus the B12s, he will be taking 6.15mg. of MethylB12 and 1.225mg. of AdB12 per day.
2 multi's/day will be taking 167mcg. calcium folinate, and 167 mcg. of L-5-methyltetrahydrofolic acid per day
Plus the Adb12 has 200 mcg. folic acid per day
So TMG should be added before SAM-e? My friend will be getting 3 mg. of P5P with new multi's (Thorne V); I bought some 50mg. of P5P but I don't want things to get out of balance; I will probably wait on that.
P.S. From the list he's an undermethylator.
When does everybody take their multi's - I was going to have him take one in a.m. after eating and then in p.m.
Also my friend is allergic to sulfates on his skin - is there a clue there re: sulfur??
About 6 weeks ago I had my B12 serum level checked and it was high 1,600 (200-1100)
I just had it checked again and have not taken any form of B12 and its higher >2,000 (200-1100)
Can anyone explain why this is happening or what it means?
Hi Nielk,
That is an increase of 2mcg content in 5 liters of blood. That can happen from a steak dinner or an order of clams. It doesn't take much. That is one of the problems with serum level cobalamin, it is volitile. Further it can also be waste cobalamin carrying toxins for excretion. It could be happening for all sorts of normal ordinary reasons and mean nothing at all.
About 6 weeks ago I had my B12 serum level checked and it was high 1,600 (200-1100)
I just had it checked again and have not taken any form of B12 and its higher >2,000 (200-1100)
Can anyone explain why this is happening or what it means?
My take on this is that I would get a homocysteine test (about $60) because that is the organic test that shows whether or not you have enough mB12, mfolate, TMG, P5P, and methionine. Perfect is 6.3. For every 3 points higher you have a 35% higher risk of stroke or cardiac event. You want to know if your body can use what you are taking and that is what an organic acid test determines. If you are at or close to 6.3 then you can try to cut back on your methylation protocol and retest. Until you determine the least you can tatke to stay on the money.
I dont trust B12 tests - they are not organic acid tests. They can say you are replete or even high when in fact your body cant even use the supplement.
Your other measures showed you have an infection going and the BUN/creatinine ratio detects kidney problems. Sometimes medications or ...? can cause kidney problems. I would find it important to find out what is bothering my kidneys. For instance, tylenol can cause kidney problems. Kidney problems will raise homocysteine, a neurotoxin. idk what causes it. But look at everything you take and ask your doctor to help you problem solve. Then retest.
Thanks rydra so much for your detailed response to me. I think you are on to something because I also have symptoms of edema - swelling in my hands, feet and stomach. I will get it checked out. I really appreciate your help.
As far as your SNP specific treatments go. How are you deciding what to do about the SNPs? Medical practitioner? Based on Yasko's protocols? Or is there more readily available information out there about nutrigenomics that I'm ignorant of? I'm in the process of getting my testing done.
Thanks Fredd,
I appreciate your response. Since the level is so high, do you think that I still need to supplement with more B12?
What does elevated serum b12 and folate in the blood of someone with malabsorption and no supplementation actually mean?
Lack of methyl groups to methylate them?
Enzyme defects?
Likely MTHFR++ and/or MTRR++?
Is there a point at which on getting the methylation cycle going that this b12 and folate in your serum would decline? ie. The methylation cycle becomes able to use these inactive forms again. (From what I've been reading lately about people developing folate deficiencies, this is a yes for folate?)
hixxy