Hi there guys, I was posting a lot about 6 weeks ago and got a lot of help from @Mary and @caledonia. After apparently going into overmethylation, I followed Caledonia's advice and stopped taking all the B vitamins, and took Nicotinic Acid a few times a few times a day, maybe for a week. That seemed to stop the crazy Potassium needs and cramps in my legs. Unfortunately, My heart rate never went back to normal, the tachyacardia, the chest pain, it became a massive source of stress for me. I had already had these symptoms - I originally started seeing a doctor nearly a year ago due to palpitations and a Holter exam about 9 months ago already found I had tachyacardia of up to 190, but in the weeks after starting the B vitamins, it just exacerbated so badly and after a few weeks was not back to normal. One day, suffering from chest pains, I just decided to go to the ER, despite awaiting a referral to a cardiologist from my GP. At the hospital they immediately rushed me through and put me on drugs to stabilise my heart rythm, saying I was tachyacardic and had an arrythmia. They later told me it was not dangerous and would refer me for an angiogram and put me on Beta-Blockers. Since taking the Beta blockers, my heart rythym has gone back to normal and I am immensely relieved. The only problem was that while I was there, they asked me why my platelets were so low - I've had well below the minimum for over a year, although my GP says it's fine. The doctor asked if I had joint pains, which, yes, became chronic and agonising since starting the B vitamins, although I had been suffering from it every 6-8 weeks for a couple of weeks for at least 6 months. I told the doctor I thought all of this, my platelets, my heart, was due to a B12 deficiency from being Vegan all my life. The doctor has referred me to an autoimmune diseases department, I don't know why. I went back to my GP and explained what had happened and asked if he could do a test to find out if I had some type of autoimmune disease because the pain was agonising and I was really stressed from now thinking I had Lupus or arthritis or something. The doctor was the cruellest doctor I have ever seen in my life. He just looked me in the eye and said 'no, there are no tests for you, because your problems are psychological, they are in your head, what you need is a psychiatrist and if you don't agree with me, change doctor'. His reaction came out of nowhere, I don't understand it and I was devastated. I went to an Osteopath twice this week, he has aligned my spine, done some massage etc, but says I have inflammation in my joints, shoulders, back, legs etc, and it's probably stress related. This week I went to a private Heamotologist, to ask his opinion about the platelets. He said the exact same thing as my GP. He said that a B12 level of 205 (non-deficiency range is considered 195-800, so I'm right on the border) is fine, the low platelets are fine, basically because I don't show anemia. He said he doesn't see anything physically wrong with me (despite the pain, and the arrythmia etc, but hey) but said I looked visibly stressed. And prescribed me anti-depressants, saying the relief from stress would alleviate all the other symptoms. I took the Escitolopram for the last 2 days. Yesterday I got dizzy and felt like a zombie and last night I woke up with a horrible pain inside me, you know like the pain when somebody breaks up with you or somebody you love dies, that kind of massive pain in your stomach, except nothing bad had happened so I know it's from the SSRI. I feel like it has made me more depressed. i know side effects are normal in the beginning, but I just don't feel good about taking this stuff. I was starting to feel better, happy, the past week. I am taking Inositol which i find really helpful, my vitamin D levels are fine, I had managed to stabilise my mood somewhat by regulating my blood sugar with Chromium, using chamomile tea and exercise to get a hang on the anxiety.... I was beginning to feel better and wanted to try 5-HTP and GABA to see if they help. I've also just started taking a mineral supplement, trace minerals, that gives 1.5 mg of Lithium every day along with 72 other minerals. I wanted to give all this stuff a try, not go on anti-depressants. I am absolutely convinced that so many of my symptoms are due to B12 deficiency. For the past week I have been dividing my Jarrow 5000MG methyl B-12 into maybe 8 or 16 pieces and just taking one piece a day, along with magensium, calcium, turmeric, vitamin D, the trace minerals etc. I have so far tolerated this fine and I intended on doubling the dose each week, so working up to a whole 5000mg maybe over 6-8 weeks. At the same time, I feel so lost and confused and afraid and alone and I would love a doctor to just say to me, this is what will work for you, you need to do this, and for me to trust everything was going to be ok, but right now I just don't know what to believe. There is a functional doctor with a qualification in nutrition in my city, I am thinking of going to him and just asking him to give me B12 shots, maybe they'll work quicker than this titrating up the B12 thing slowly, but I read this article which explains the dangers of B6 for some people (I totally think it was the B6 that made things go 'bad' for me) and that some people, say with mitral valve prolapse and arrythmias like me, should not take B12 shots. http://www.acu-cell.com/bx.html I am sorry to ask yet another, massively long question, but does anybody have any advice? Apart from all the physical stuff that's come up, what I really want to treat is on-off depression (sometimes I feel fine for weeks then suddenly have a momentous crash from nowhere) near constant anxiety and irritability, sensitivity to noise and feeling kind of hyper all the time. Again, I have been Vegan my whole life, and was diagnosed with Aspergers syndrome about 4 months ago. Thank you immensely, yet again, and I hope you are each doing well.