Volunteer opportunity: Organizing Phoenix Rising articles
This section contains all the articles that have been published by Phoenix Rising over the years. As you will see if you browse here, some of the articles are outdated--either the research has been superseded or retracted or the article features an event or campaign that is now in...
Discuss the article on the Forums.

Association of mitochondrial DNA variants with me/cfs [published commentary]

Discussion in 'Latest ME/CFS Research' started by Kati, Dec 20, 2016.

  1. Kati

    Kati Patient in training

    Messages:
    5,475
    Likes:
    19,642
    Association of mitochondrial DNA variants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms

    Maureen R. Hanson Zhenglong Gu, Alon Keinan, Kaixiong Ye, Arnaud Germain and Paul Billing-Ross
    http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-1104-5

    Abstract

    Earlier this year, we described an analysis of mitochondrial DNA (mtDNA) variants in myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) patients and healthy controls.

    We reported that there was no significant association of haplogroups or singe nucleotide polymorphisms (SNPs) with disease status.

    Nevertheless, a commentary about our paper appeared (Finsterer and Zarrouk-Mahjoub. J Transl Med14:182, 2016) that criticized the association of mtDNA haplogroups with ME/CFS, a conclusion that was absent from our paper.

    The aforementioned commentary also demanded experiments that were outside of the scope of our study, ones that we had suggested as follow-up studies.

    Because they failed to consult a published and cited report describing the cohorts we studied, the authors also cast aspersions on the method of selection of cases for inclusion.

    We reiterate that we observed statistically significant association of mtDNA variants with particular symptoms and their severity, though we observed no association with disease status.

    Link to original paper: http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0771-6
    Link to comment to this paper: http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0939-0
     
    Last edited: Dec 20, 2016

See more popular forum discussions.

Share This Page