International ME/CFS and FM Awareness Day Is On May 12, 2018
Thomas Hennessy, Jr., selected May 12th to be our international awareness day back in 1992. He knew that May 12th had also been the birthday of Florence Nightingale. She was the English army nurse who helped to found the Red Cross as well as the first school of nursing in the world.
Discuss the article on the Forums.

Article: Comedown at CROI: XMRV and CFS at the Conference on Retroviruses and Opportunistic Infectio

Discussion in 'Phoenix Rising Articles' started by Phoenix Rising Team, Mar 7, 2011.

  1. Cort

    Cort Phoenix Rising Founder

    Thanks, I was just thinking about going to the video.

    I did see here

    I wonder if they know all the strains used to passage the xenograft?

    Interesting idea about androgen independence. I imagine that it didn't help XMRV - I guess it depends on the efficacy of their tests - which I imagine is quite good - but that is something else to think about.
  2. Something to consider. The introduction of nude mice into research laboratories about coincides with the first recorded outbreak of ME (Los Angeles, 1934).

    Although the first official batch is ascribed to Bethesda, Maryland, there was earlier stock. They all seem to orginate from 9 mice brought from Lausanne, Switzerland in 1926 by a Clara Lynch. The trail then goes to Harlan Laboratories that have a site in Placentia, in the Greater Los Angeles Area, but I have no info on when they arrived there (Harlan Laboratories was founded in Indianapolis in 1931 and then quickly expanded.)

    By the way, has XMRV or pre-XMRV been detected in hamsters?
  3. lansbergen

    lansbergen Senior Member

    I can not find any in vivo tests.

    PubMed gives three hits

    An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.

    Six host range variants of the xenotropic/polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor.

    Evolution of functional and sequence variants of the mammalian XPR1 receptor for mouse xenotropic gammaretroviruses and the human-derived retrovirus XMRV.

  4. Thanks, Toos.

    Note that many pet hamsters stem from laboratory hamsters that were introduced during WW II; they quickly became very popular. See .

    I seem to remember that endemic cases of ME began to get noticed shortly after in the UK.

    What if the lab mice infected the lab hamsters (or perhaps they were already carriers, too)?
    Does pre-XMRV combine to XMRV in hamsters? Pet hamsters often have little defense against infections.
    How many of us had pet hamsters at home? My family had several, when I first got mononucleosis. Three of us later got a disease that has been linked to XMRV.
  5. lansbergen

    lansbergen Senior Member

    We did not have hamsters or any rodents as pets.

    When I was a kid we had rabbits that were kept for food. There were big wild rats in the barn. Mice were everywhere in rural.

See more popular forum discussions.

Share This Page